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Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome
The profiles of sensitization based on component-resolved diagnosis (CRD) differ from region to region in populations sensitized to birch pollen. We investigated the endotypes of birch pollen-sensitized Korean children with allergic diseases using CRD and distinguished the endotypes of oral allergy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478691/ https://www.ncbi.nlm.nih.gov/pubmed/32150106 http://dx.doi.org/10.1097/MD.0000000000019469 |
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author | Baek, Hey-Sung Jeong, Jae-Won Lee, Ha-Baik Kwon, Jae-Woo |
author_facet | Baek, Hey-Sung Jeong, Jae-Won Lee, Ha-Baik Kwon, Jae-Woo |
author_sort | Baek, Hey-Sung |
collection | PubMed |
description | The profiles of sensitization based on component-resolved diagnosis (CRD) differ from region to region in populations sensitized to birch pollen. We investigated the endotypes of birch pollen-sensitized Korean children with allergic diseases using CRD and distinguished the endotypes of oral allergy syndrome (OAS) among them. Thirty-one birch pollen-sensitized children with allergic diseases were enrolled. Specific immunoglobulin E (IgE) to birch pollen and fruit including apple, peach, and kiwi were evaluated via skin prick tests and ImmunoCAP in all subjects. Sensitization profiles based on CRD were evaluated with the Immuno-solid-phase Allergen Chip for birch pollen-sensitization using birch pollen components (Bet v 1, Bet v 2, and Bet v 4), and for OAS using the allergen families pathogenesis-related class 10 proteins (PR-10), lipid transfer proteins, and profilin. All patients (n = 13) with OAS were sensitive to Bet v 1. However, 61% (11/18) of patients without OAS were sensitized to Bet v 1. The level of specific IgE to Bet v 1 was higher in patients with OAS than in those without OAS. All birch pollen-sensitized Korean children with OAS were sensitized to PR-10, and 69% (9/13) of them were mono-sensitized to PR-10. Among patients without OAS, 33% (6/18) were not sensitized to any of the allergen families. Birch pollen-sensitized Korean children with allergic diseases showed unique patterns of sensitization to Bet v 1, Bet v 2, and Bet v 4, and the sensitization profiles based on CRD were totally different according to the presence of OAS. |
format | Online Article Text |
id | pubmed-7478691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-74786912020-09-24 Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome Baek, Hey-Sung Jeong, Jae-Won Lee, Ha-Baik Kwon, Jae-Woo Medicine (Baltimore) 3600 The profiles of sensitization based on component-resolved diagnosis (CRD) differ from region to region in populations sensitized to birch pollen. We investigated the endotypes of birch pollen-sensitized Korean children with allergic diseases using CRD and distinguished the endotypes of oral allergy syndrome (OAS) among them. Thirty-one birch pollen-sensitized children with allergic diseases were enrolled. Specific immunoglobulin E (IgE) to birch pollen and fruit including apple, peach, and kiwi were evaluated via skin prick tests and ImmunoCAP in all subjects. Sensitization profiles based on CRD were evaluated with the Immuno-solid-phase Allergen Chip for birch pollen-sensitization using birch pollen components (Bet v 1, Bet v 2, and Bet v 4), and for OAS using the allergen families pathogenesis-related class 10 proteins (PR-10), lipid transfer proteins, and profilin. All patients (n = 13) with OAS were sensitive to Bet v 1. However, 61% (11/18) of patients without OAS were sensitized to Bet v 1. The level of specific IgE to Bet v 1 was higher in patients with OAS than in those without OAS. All birch pollen-sensitized Korean children with OAS were sensitized to PR-10, and 69% (9/13) of them were mono-sensitized to PR-10. Among patients without OAS, 33% (6/18) were not sensitized to any of the allergen families. Birch pollen-sensitized Korean children with allergic diseases showed unique patterns of sensitization to Bet v 1, Bet v 2, and Bet v 4, and the sensitization profiles based on CRD were totally different according to the presence of OAS. Wolters Kluwer Health 2020-03-06 /pmc/articles/PMC7478691/ /pubmed/32150106 http://dx.doi.org/10.1097/MD.0000000000019469 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 3600 Baek, Hey-Sung Jeong, Jae-Won Lee, Ha-Baik Kwon, Jae-Woo Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome |
title | Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome |
title_full | Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome |
title_fullStr | Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome |
title_full_unstemmed | Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome |
title_short | Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome |
title_sort | molecular sensitization patterns in birch pollen-sensitized korean children according to the presence of oral allergy syndrome |
topic | 3600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478691/ https://www.ncbi.nlm.nih.gov/pubmed/32150106 http://dx.doi.org/10.1097/MD.0000000000019469 |
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