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Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas

The present study aimed to develop an effective nomogram for predicting the overall survival (OS) of patients with cerebral anaplastic glioma (AG). This study included 1939 patients diagnosed with AG between 1973 and 2013 who were identified using the Surveillance, Epidemiology, and End Results data...

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Autores principales: Zhao, Ye-Yu, Wan, Qin-Si, Hao, Zheng, Zhu, Hua-Xin, Xing, Ze-Long, Li, Mei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478695/
https://www.ncbi.nlm.nih.gov/pubmed/32150092
http://dx.doi.org/10.1097/MD.0000000000019416
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author Zhao, Ye-Yu
Wan, Qin-Si
Hao, Zheng
Zhu, Hua-Xin
Xing, Ze-Long
Li, Mei-Hua
author_facet Zhao, Ye-Yu
Wan, Qin-Si
Hao, Zheng
Zhu, Hua-Xin
Xing, Ze-Long
Li, Mei-Hua
author_sort Zhao, Ye-Yu
collection PubMed
description The present study aimed to develop an effective nomogram for predicting the overall survival (OS) of patients with cerebral anaplastic glioma (AG). This study included 1939 patients diagnosed with AG between 1973 and 2013 who were identified using the Surveillance, Epidemiology, and End Results database. A multivariate Cox regression analysis revealed that age, histology, tumor site, marital status, radiotherapy, and surgery were independent prognostic factors and, thus, these factors were selected to build a clinical nomogram. Harrell's concordance index (C-index) and a calibration curve were formulated to evaluate the discrimination and calibration of the nomogram using bootstrapping. A nomogram was developed to predict 5- and 9-year OS rates based on 6 independent prognostic factors identified in the training set: age, tumor site, marital status, histology, radiotherapy, and surgery (P < .05). The Harrell's concordance index values of the training and validation sets were 0.776 (0.759–0.793) and 0.766 (0.739–0.792), respectively. The calibration curve exhibited good consistency with the actual observation curve in both sets. Although the prognostic value of the World Health Organization (WHO) classification has been validated, we developed a novel nomogram based on readily available clinical variables in terms of demographic data, therapeutic modalities, and tumor characteristics to predict the survival of AG patients. When used in combination with the WHO classification system, this clinical nomogram can aid clinicians in making individualized predictions of AG patient survival and improving treatment strategies.
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spelling pubmed-74786952020-09-24 Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas Zhao, Ye-Yu Wan, Qin-Si Hao, Zheng Zhu, Hua-Xin Xing, Ze-Long Li, Mei-Hua Medicine (Baltimore) 5700 The present study aimed to develop an effective nomogram for predicting the overall survival (OS) of patients with cerebral anaplastic glioma (AG). This study included 1939 patients diagnosed with AG between 1973 and 2013 who were identified using the Surveillance, Epidemiology, and End Results database. A multivariate Cox regression analysis revealed that age, histology, tumor site, marital status, radiotherapy, and surgery were independent prognostic factors and, thus, these factors were selected to build a clinical nomogram. Harrell's concordance index (C-index) and a calibration curve were formulated to evaluate the discrimination and calibration of the nomogram using bootstrapping. A nomogram was developed to predict 5- and 9-year OS rates based on 6 independent prognostic factors identified in the training set: age, tumor site, marital status, histology, radiotherapy, and surgery (P < .05). The Harrell's concordance index values of the training and validation sets were 0.776 (0.759–0.793) and 0.766 (0.739–0.792), respectively. The calibration curve exhibited good consistency with the actual observation curve in both sets. Although the prognostic value of the World Health Organization (WHO) classification has been validated, we developed a novel nomogram based on readily available clinical variables in terms of demographic data, therapeutic modalities, and tumor characteristics to predict the survival of AG patients. When used in combination with the WHO classification system, this clinical nomogram can aid clinicians in making individualized predictions of AG patient survival and improving treatment strategies. Wolters Kluwer Health 2020-03-06 /pmc/articles/PMC7478695/ /pubmed/32150092 http://dx.doi.org/10.1097/MD.0000000000019416 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Zhao, Ye-Yu
Wan, Qin-Si
Hao, Zheng
Zhu, Hua-Xin
Xing, Ze-Long
Li, Mei-Hua
Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas
title Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas
title_full Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas
title_fullStr Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas
title_full_unstemmed Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas
title_short Clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas
title_sort clinical nomogram for predicting the survival of patients with cerebral anaplastic gliomas
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478695/
https://www.ncbi.nlm.nih.gov/pubmed/32150092
http://dx.doi.org/10.1097/MD.0000000000019416
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