RSSs set the odds for exclusion

In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that V(β)-to-D(β)J(β) rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal V(β) recombination signal sequences limiting synchronous rearr...

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Detalles Bibliográficos
Autor principal: Krangel, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478726/
https://www.ncbi.nlm.nih.gov/pubmed/32793983
http://dx.doi.org/10.1084/jem.20200831
Descripción
Sumario:In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that V(β)-to-D(β)J(β) rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal V(β) recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.

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