RSSs set the odds for exclusion

In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that V(β)-to-D(β)J(β) rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal V(β) recombination signal sequences limiting synchronous rearr...

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Detalles Bibliográficos
Autor principal: Krangel, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478726/
https://www.ncbi.nlm.nih.gov/pubmed/32793983
http://dx.doi.org/10.1084/jem.20200831
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author Krangel, Michael S.
author_facet Krangel, Michael S.
author_sort Krangel, Michael S.
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description In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that V(β)-to-D(β)J(β) rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal V(β) recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.
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spelling pubmed-74787262021-03-07 RSSs set the odds for exclusion Krangel, Michael S. J Exp Med Insights In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that V(β)-to-D(β)J(β) rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal V(β) recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion. Rockefeller University Press 2020-08-13 /pmc/articles/PMC7478726/ /pubmed/32793983 http://dx.doi.org/10.1084/jem.20200831 Text en © 2020 Krangel http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Krangel, Michael S.
RSSs set the odds for exclusion
title RSSs set the odds for exclusion
title_full RSSs set the odds for exclusion
title_fullStr RSSs set the odds for exclusion
title_full_unstemmed RSSs set the odds for exclusion
title_short RSSs set the odds for exclusion
title_sort rsss set the odds for exclusion
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478726/
https://www.ncbi.nlm.nih.gov/pubmed/32793983
http://dx.doi.org/10.1084/jem.20200831
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