Cargando…
RSSs set the odds for exclusion
In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that V(β)-to-D(β)J(β) rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal V(β) recombination signal sequences limiting synchronous rearr...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478726/ https://www.ncbi.nlm.nih.gov/pubmed/32793983 http://dx.doi.org/10.1084/jem.20200831 |