Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis

Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but pathogenic mechanisms are still poorly understood. Here, we show that podocyte expression of decay-accelerating factor (DAF/CD55), a complement C3 convertase regulator, crucially controls disease in murine models of adria...

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Detalles Bibliográficos
Autores principales: Angeletti, Andrea, Cantarelli, Chiara, Petrosyan, Astgik, Andrighetto, Sofia, Budge, Kelly, D’Agati, Vivette D., Hartzell, Susan, Malvi, Deborah, Donadei, Chiara, Thurman, Joshua M., Galešić-Ljubanović, Danica, He, John Cijiang, Xiao, Wenzhen, Campbell, Kirk N., Wong, Jenny, Fischman, Clara, Manrique, Joaquin, Zaza, Gianluigi, Fiaccadori, Enrico, La Manna, Gaetano, Fribourg, Miguel, Leventhal, Jeremy, Da Sacco, Stefano, Perin, Laura, Heeger, Peter S., Cravedi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478737/
https://www.ncbi.nlm.nih.gov/pubmed/32717081
http://dx.doi.org/10.1084/jem.20191699

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