SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have been shown to promote PDAC. However, the changes in cholesterol metabolism and their role during PDAC progression remain lar...

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Detalles Bibliográficos
Autores principales: Oni, Tobiloba E., Biffi, Giulia, Baker, Lindsey A., Hao, Yuan, Tonelli, Claudia, Somerville, Tim D.D., Deschênes, Astrid, Belleau, Pascal, Hwang, Chang-il, Sánchez-Rivera, Francisco J., Cox, Hilary, Brosnan, Erin, Doshi, Abhishek, Lumia, Rebecca P., Khaledi, Kimia, Park, Youngkyu, Trotman, Lloyd C., Lowe, Scott W., Krasnitz, Alexander, Vakoc, Christopher R., Tuveson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478739/
https://www.ncbi.nlm.nih.gov/pubmed/32633781
http://dx.doi.org/10.1084/jem.20192389

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