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Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta

Upon Ca(2+) store depletion, Orai1 channels cluster and open at endoplasmic reticulum–plasma membrane (ER–PM) junctions in signaling complexes called puncta. Little is known about whether and how Orai1 channel activity may vary between individual puncta. Previously, we developed and validated optica...

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Detalles Bibliográficos
Autores principales:	Dynes, Joseph L., Yeromin, Andriy V., Cahalan, Michael D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478869/ https://www.ncbi.nlm.nih.gov/pubmed/32589186 http://dx.doi.org/10.1085/jgp.201812239

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