Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

Vascular dysfunctions are a common feature of multiple age-related diseases. However, modeling healthy and pathological aging of the human vasculature represents an unresolved experimental challenge. Here, we generated induced vascular endothelial cells (iVECs) and smooth muscle cells (iSMCs) by dir...

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Detalles Bibliográficos
Autores principales: Bersini, Simone, Schulte, Roberta, Huang, Ling, Tsai, Hannah, Hetzer, Martin W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478891/
https://www.ncbi.nlm.nih.gov/pubmed/32896271
http://dx.doi.org/10.7554/eLife.54383

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