Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish

Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic disorder characterized by altered skeletal development and extraskeletal ossification. All cases of FOP are caused by activating mutations in the type I BMP/TGFβ cell surface receptor ACVR1, which over-activates signaling through ph...

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Detalles Bibliográficos
Autores principales: Allen, Robyn S, Tajer, Benjamin, Shore, Eileen M, Mullins, Mary C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478894/
https://www.ncbi.nlm.nih.gov/pubmed/32897189
http://dx.doi.org/10.7554/eLife.53761

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