Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor

We present a case report of vascular transformation of lymph node sinuses (VTS) of nodular spindle cell variant. This variation is a rare, benign entity previously described with histopathologic transformation of lymph node sinuses into spindle cell nodules with or without vascular channels and asso...

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Detalles Bibliográficos
Autores principales: Chai, Jocelyn, Hamilton, Trevor, Han-Lee, Cheng, Feng, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478933/
https://www.ncbi.nlm.nih.gov/pubmed/32923233
http://dx.doi.org/10.7759/cureus.9632
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author Chai, Jocelyn
Hamilton, Trevor
Han-Lee, Cheng
Feng, Xiaolan
author_facet Chai, Jocelyn
Hamilton, Trevor
Han-Lee, Cheng
Feng, Xiaolan
author_sort Chai, Jocelyn
collection PubMed
description We present a case report of vascular transformation of lymph node sinuses (VTS) of nodular spindle cell variant. This variation is a rare, benign entity previously described with histopathologic transformation of lymph node sinuses into spindle cell nodules with or without vascular channels and associated sinusoidal fibrosis. This case highlights the diagnostic pitfall of discovered on GIST1 (DOG1) immunohistochemical staining of this entity, contributing to the initial misdiagnosis as metastatic gastrointestinal stromal tumor (GIST). To our knowledge, this is the first reported case of a patient with VTS and DOG1 positivity. 
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spelling pubmed-74789332020-09-11 Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor Chai, Jocelyn Hamilton, Trevor Han-Lee, Cheng Feng, Xiaolan Cureus Pathology We present a case report of vascular transformation of lymph node sinuses (VTS) of nodular spindle cell variant. This variation is a rare, benign entity previously described with histopathologic transformation of lymph node sinuses into spindle cell nodules with or without vascular channels and associated sinusoidal fibrosis. This case highlights the diagnostic pitfall of discovered on GIST1 (DOG1) immunohistochemical staining of this entity, contributing to the initial misdiagnosis as metastatic gastrointestinal stromal tumor (GIST). To our knowledge, this is the first reported case of a patient with VTS and DOG1 positivity.  Cureus 2020-08-09 /pmc/articles/PMC7478933/ /pubmed/32923233 http://dx.doi.org/10.7759/cureus.9632 Text en Copyright © 2020, Chai et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Chai, Jocelyn
Hamilton, Trevor
Han-Lee, Cheng
Feng, Xiaolan
Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor
title Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor
title_full Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor
title_fullStr Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor
title_full_unstemmed Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor
title_short Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor
title_sort nodular spindle cell vascular transformation in pelvic lymph nodes with discovered on gist1 (dog1) positivity mimicking metastatic gastrointestinal stromal tumor
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478933/
https://www.ncbi.nlm.nih.gov/pubmed/32923233
http://dx.doi.org/10.7759/cureus.9632
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