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Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors
Although the majority of gastrointestinal stromal tumors (GISTs) possess KIT mutations that induce constitutive signal transduction, the clinical outcomes are variable. The ETS translocation variant 1 (ETV1) gene encodes a transcription factor that is reported to cooperate with KIT in GISTs. However...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478956/ https://www.ncbi.nlm.nih.gov/pubmed/32901065 http://dx.doi.org/10.1038/s41598-020-71719-y |
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author | Sakamaki, Keiichi Funasaka, Kohei Miyahara, Ryoji Furukawa, Kazuhiro Yamamura, Takeshi Ohno, Eizaburo Nakamura, Masanao Kawashima, Hiroki Hirooka, Yoshiki Fujishiro, Mitsuhiro Goto, Hidemi |
author_facet | Sakamaki, Keiichi Funasaka, Kohei Miyahara, Ryoji Furukawa, Kazuhiro Yamamura, Takeshi Ohno, Eizaburo Nakamura, Masanao Kawashima, Hiroki Hirooka, Yoshiki Fujishiro, Mitsuhiro Goto, Hidemi |
author_sort | Sakamaki, Keiichi |
collection | PubMed |
description | Although the majority of gastrointestinal stromal tumors (GISTs) possess KIT mutations that induce constitutive signal transduction, the clinical outcomes are variable. The ETS translocation variant 1 (ETV1) gene encodes a transcription factor that is reported to cooperate with KIT in GISTs. However, the clinical role of ETV1 is largely unknown. The aim of this study was to examine ETV1 expression and its associations with clinical features in GISTs. We conducted a cohort study involving 64 patients with GISTs who underwent surgical resection between October 2008 and February 2015. ETV1 mRNA expression was compared with that in non-GISTs and was analyzed among risk classifications or clinical outcomes. The GIST samples exhibited significantly higher ETV1 mRNA expression than the non-GIST samples (P < 0.0001). Sixty-four GISTs were stratified into high or low ETV1 mRNA expression groups based on the median relative abundance of ETV1 mRNA. The multivariate analysis showed that low ETV1 expression, as well as tumor size and mitotic index, was an independent factor of recurrence (hazard ratio: 8.1). Patients with high ETV1 expression achieved significantly longer recurrence-free survival (RFS) times than those with low ETV1 expression (P = 0.025). Our study revealed that low ETV1 expression is an independent factor of recurrence after surgery in patients with GISTs, and thus, low ETV1 expression might be a marker of more aggressive malignant GISTs. |
format | Online Article Text |
id | pubmed-7478956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74789562020-09-11 Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors Sakamaki, Keiichi Funasaka, Kohei Miyahara, Ryoji Furukawa, Kazuhiro Yamamura, Takeshi Ohno, Eizaburo Nakamura, Masanao Kawashima, Hiroki Hirooka, Yoshiki Fujishiro, Mitsuhiro Goto, Hidemi Sci Rep Article Although the majority of gastrointestinal stromal tumors (GISTs) possess KIT mutations that induce constitutive signal transduction, the clinical outcomes are variable. The ETS translocation variant 1 (ETV1) gene encodes a transcription factor that is reported to cooperate with KIT in GISTs. However, the clinical role of ETV1 is largely unknown. The aim of this study was to examine ETV1 expression and its associations with clinical features in GISTs. We conducted a cohort study involving 64 patients with GISTs who underwent surgical resection between October 2008 and February 2015. ETV1 mRNA expression was compared with that in non-GISTs and was analyzed among risk classifications or clinical outcomes. The GIST samples exhibited significantly higher ETV1 mRNA expression than the non-GIST samples (P < 0.0001). Sixty-four GISTs were stratified into high or low ETV1 mRNA expression groups based on the median relative abundance of ETV1 mRNA. The multivariate analysis showed that low ETV1 expression, as well as tumor size and mitotic index, was an independent factor of recurrence (hazard ratio: 8.1). Patients with high ETV1 expression achieved significantly longer recurrence-free survival (RFS) times than those with low ETV1 expression (P = 0.025). Our study revealed that low ETV1 expression is an independent factor of recurrence after surgery in patients with GISTs, and thus, low ETV1 expression might be a marker of more aggressive malignant GISTs. Nature Publishing Group UK 2020-09-08 /pmc/articles/PMC7478956/ /pubmed/32901065 http://dx.doi.org/10.1038/s41598-020-71719-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sakamaki, Keiichi Funasaka, Kohei Miyahara, Ryoji Furukawa, Kazuhiro Yamamura, Takeshi Ohno, Eizaburo Nakamura, Masanao Kawashima, Hiroki Hirooka, Yoshiki Fujishiro, Mitsuhiro Goto, Hidemi Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors |
title | Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors |
title_full | Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors |
title_fullStr | Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors |
title_full_unstemmed | Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors |
title_short | Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors |
title_sort | low etv1 mrna expression is associated with recurrence in gastrointestinal stromal tumors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478956/ https://www.ncbi.nlm.nih.gov/pubmed/32901065 http://dx.doi.org/10.1038/s41598-020-71719-y |
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