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Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction
The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals. In response to the Frontiers Research Topic, “Coronavirus disease (COVI...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479061/ https://www.ncbi.nlm.nih.gov/pubmed/32984339 http://dx.doi.org/10.3389/fcell.2020.00856 |
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author | Westmark, Cara J. Kiso, Maki Halfmann, Peter Westmark, Pamela R. Kawaoka, Yoshihiro |
author_facet | Westmark, Cara J. Kiso, Maki Halfmann, Peter Westmark, Pamela R. Kawaoka, Yoshihiro |
author_sort | Westmark, Cara J. |
collection | PubMed |
description | The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals. In response to the Frontiers Research Topic, “Coronavirus disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management, and Public Health Response,” this Hypothesis article proposes a novel therapeutic strategy to repurpose metabotropic glutamate 5 receptor (mGluR(5)) inhibitors to interfere with viral hijacking of the host protein synthesis machinery. We review pertinent background on SARS-CoV-2, fragile X syndrome (FXS) and metabotropic glutamate receptor 5 (mGluR(5)) and provide a mechanistic-based hypothesis and preliminary data to support testing mGluR(5) inhibitors in COVID-19 research. |
format | Online Article Text |
id | pubmed-7479061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74790612020-09-26 Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction Westmark, Cara J. Kiso, Maki Halfmann, Peter Westmark, Pamela R. Kawaoka, Yoshihiro Front Cell Dev Biol Cell and Developmental Biology The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals. In response to the Frontiers Research Topic, “Coronavirus disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management, and Public Health Response,” this Hypothesis article proposes a novel therapeutic strategy to repurpose metabotropic glutamate 5 receptor (mGluR(5)) inhibitors to interfere with viral hijacking of the host protein synthesis machinery. We review pertinent background on SARS-CoV-2, fragile X syndrome (FXS) and metabotropic glutamate receptor 5 (mGluR(5)) and provide a mechanistic-based hypothesis and preliminary data to support testing mGluR(5) inhibitors in COVID-19 research. Frontiers Media S.A. 2020-08-26 /pmc/articles/PMC7479061/ /pubmed/32984339 http://dx.doi.org/10.3389/fcell.2020.00856 Text en Copyright © 2020 Westmark, Kiso, Halfmann, Westmark and Kawaoka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Westmark, Cara J. Kiso, Maki Halfmann, Peter Westmark, Pamela R. Kawaoka, Yoshihiro Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction |
title | Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction |
title_full | Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction |
title_fullStr | Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction |
title_full_unstemmed | Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction |
title_short | Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction |
title_sort | repurposing fragile x drugs to inhibit sars-cov-2 viral reproduction |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479061/ https://www.ncbi.nlm.nih.gov/pubmed/32984339 http://dx.doi.org/10.3389/fcell.2020.00856 |
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