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Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy
Glioblastoma is the most malignancy tumor generated from the central nervous system along with median survival time less than 14.6 months. Pentraxin 3 has been proved its association with patients’ poor survival outcome in various tumor. Recently, several studies revealed its association with gliobl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479068/ https://www.ncbi.nlm.nih.gov/pubmed/32984316 http://dx.doi.org/10.3389/fcell.2020.00795 |
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author | Wang, Zeyu Wang, Xing Zhang, Nan Zhang, Hao Dai, Ziyu Zhang, Mingyu Feng, Songshan Cheng, Quan |
author_facet | Wang, Zeyu Wang, Xing Zhang, Nan Zhang, Hao Dai, Ziyu Zhang, Mingyu Feng, Songshan Cheng, Quan |
author_sort | Wang, Zeyu |
collection | PubMed |
description | Glioblastoma is the most malignancy tumor generated from the central nervous system along with median survival time less than 14.6 months. Pentraxin 3 has been proved its association with patients’ poor survival outcome in various tumor. Recently, several studies revealed its association with glioblastoma progression but the mechanism is remained unknown. Autophagy is a programmed cells death and acts critical role in tumor progression. In this study, pentraxin 3 is recognized as prognostic prediction biomarker of glioblastoma and can promote glioblastoma progression through negative modulating tumor cells autophagy. Transcription factor JUN is assumed to participate in cells autophagy modulation by regulating pentraxin 3 expression. This work reveals novel mechanism of pentraxin 3 mediated glioblastoma progression. Furthermore, JUN is identified as potential transcription factor involves in pentraxin 3 mediated tumor cells autophagy. |
format | Online Article Text |
id | pubmed-7479068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74790682020-09-26 Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy Wang, Zeyu Wang, Xing Zhang, Nan Zhang, Hao Dai, Ziyu Zhang, Mingyu Feng, Songshan Cheng, Quan Front Cell Dev Biol Cell and Developmental Biology Glioblastoma is the most malignancy tumor generated from the central nervous system along with median survival time less than 14.6 months. Pentraxin 3 has been proved its association with patients’ poor survival outcome in various tumor. Recently, several studies revealed its association with glioblastoma progression but the mechanism is remained unknown. Autophagy is a programmed cells death and acts critical role in tumor progression. In this study, pentraxin 3 is recognized as prognostic prediction biomarker of glioblastoma and can promote glioblastoma progression through negative modulating tumor cells autophagy. Transcription factor JUN is assumed to participate in cells autophagy modulation by regulating pentraxin 3 expression. This work reveals novel mechanism of pentraxin 3 mediated glioblastoma progression. Furthermore, JUN is identified as potential transcription factor involves in pentraxin 3 mediated tumor cells autophagy. Frontiers Media S.A. 2020-08-26 /pmc/articles/PMC7479068/ /pubmed/32984316 http://dx.doi.org/10.3389/fcell.2020.00795 Text en Copyright © 2020 Wang, Wang, Zhang, Zhang, Dai, Zhang, Feng and Cheng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wang, Zeyu Wang, Xing Zhang, Nan Zhang, Hao Dai, Ziyu Zhang, Mingyu Feng, Songshan Cheng, Quan Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy |
title | Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy |
title_full | Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy |
title_fullStr | Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy |
title_full_unstemmed | Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy |
title_short | Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy |
title_sort | pentraxin 3 promotes glioblastoma progression by negative regulating cells autophagy |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479068/ https://www.ncbi.nlm.nih.gov/pubmed/32984316 http://dx.doi.org/10.3389/fcell.2020.00795 |
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