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Integration of molecular profiles in a longitudinal wellness profiling cohort
An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolom...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479148/ https://www.ncbi.nlm.nih.gov/pubmed/32900998 http://dx.doi.org/10.1038/s41467-020-18148-7 |
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| author | Tebani, Abdellah Gummesson, Anders Zhong, Wen Koistinen, Ina Schuppe Lakshmikanth, Tadepally Olsson, Lisa M. Boulund, Fredrik Neiman, Maja Stenlund, Hans Hellström, Cecilia Karlsson, Max J. Arif, Muhammad Dodig-Crnković, Tea Mardinoglu, Adil Lee, Sunjae Zhang, Cheng Chen, Yang Olin, Axel Mikes, Jaromir Danielsson, Hanna von Feilitzen, Kalle Jansson, Per-Anders Angerås, Oskar Huss, Mikael Kjellqvist, Sanela Odeberg, Jacob Edfors, Fredrik Tremaroli, Valentina Forsström, Björn Schwenk, Jochen M. Nilsson, Peter Moritz, Thomas Bäckhed, Fredrik Engstrand, Lars Brodin, Petter Bergström, Göran Uhlen, Mathias Fagerberg, Linn |
| author_facet | Tebani, Abdellah Gummesson, Anders Zhong, Wen Koistinen, Ina Schuppe Lakshmikanth, Tadepally Olsson, Lisa M. Boulund, Fredrik Neiman, Maja Stenlund, Hans Hellström, Cecilia Karlsson, Max J. Arif, Muhammad Dodig-Crnković, Tea Mardinoglu, Adil Lee, Sunjae Zhang, Cheng Chen, Yang Olin, Axel Mikes, Jaromir Danielsson, Hanna von Feilitzen, Kalle Jansson, Per-Anders Angerås, Oskar Huss, Mikael Kjellqvist, Sanela Odeberg, Jacob Edfors, Fredrik Tremaroli, Valentina Forsström, Björn Schwenk, Jochen M. Nilsson, Peter Moritz, Thomas Bäckhed, Fredrik Engstrand, Lars Brodin, Petter Bergström, Göran Uhlen, Mathias Fagerberg, Linn |
| author_sort | Tebani, Abdellah |
| collection | PubMed |
| description | An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine. |
| format | Online Article Text |
| id | pubmed-7479148 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74791482020-09-21 Integration of molecular profiles in a longitudinal wellness profiling cohort Tebani, Abdellah Gummesson, Anders Zhong, Wen Koistinen, Ina Schuppe Lakshmikanth, Tadepally Olsson, Lisa M. Boulund, Fredrik Neiman, Maja Stenlund, Hans Hellström, Cecilia Karlsson, Max J. Arif, Muhammad Dodig-Crnković, Tea Mardinoglu, Adil Lee, Sunjae Zhang, Cheng Chen, Yang Olin, Axel Mikes, Jaromir Danielsson, Hanna von Feilitzen, Kalle Jansson, Per-Anders Angerås, Oskar Huss, Mikael Kjellqvist, Sanela Odeberg, Jacob Edfors, Fredrik Tremaroli, Valentina Forsström, Björn Schwenk, Jochen M. Nilsson, Peter Moritz, Thomas Bäckhed, Fredrik Engstrand, Lars Brodin, Petter Bergström, Göran Uhlen, Mathias Fagerberg, Linn Nat Commun Article An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine. Nature Publishing Group UK 2020-09-08 /pmc/articles/PMC7479148/ /pubmed/32900998 http://dx.doi.org/10.1038/s41467-020-18148-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Tebani, Abdellah Gummesson, Anders Zhong, Wen Koistinen, Ina Schuppe Lakshmikanth, Tadepally Olsson, Lisa M. Boulund, Fredrik Neiman, Maja Stenlund, Hans Hellström, Cecilia Karlsson, Max J. Arif, Muhammad Dodig-Crnković, Tea Mardinoglu, Adil Lee, Sunjae Zhang, Cheng Chen, Yang Olin, Axel Mikes, Jaromir Danielsson, Hanna von Feilitzen, Kalle Jansson, Per-Anders Angerås, Oskar Huss, Mikael Kjellqvist, Sanela Odeberg, Jacob Edfors, Fredrik Tremaroli, Valentina Forsström, Björn Schwenk, Jochen M. Nilsson, Peter Moritz, Thomas Bäckhed, Fredrik Engstrand, Lars Brodin, Petter Bergström, Göran Uhlen, Mathias Fagerberg, Linn Integration of molecular profiles in a longitudinal wellness profiling cohort |
| title | Integration of molecular profiles in a longitudinal wellness profiling cohort |
| title_full | Integration of molecular profiles in a longitudinal wellness profiling cohort |
| title_fullStr | Integration of molecular profiles in a longitudinal wellness profiling cohort |
| title_full_unstemmed | Integration of molecular profiles in a longitudinal wellness profiling cohort |
| title_short | Integration of molecular profiles in a longitudinal wellness profiling cohort |
| title_sort | integration of molecular profiles in a longitudinal wellness profiling cohort |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479148/ https://www.ncbi.nlm.nih.gov/pubmed/32900998 http://dx.doi.org/10.1038/s41467-020-18148-7 |
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