The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in ca...

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Autores principales: Salehi, Bahare, Sharifi-Rad, Javad, Cappellini, Francesca, Reiner, Željko, Zorzan, Debora, Imran, Muhammad, Sener, Bilge, Kilic, Mehtap, El-Shazly, Mohamed, Fahmy, Nouran M., Al-Sayed, Eman, Martorell, Miquel, Tonelli, Chiara, Petroni, Katia, Docea, Anca Oana, Calina, Daniela, Maroyi, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479177/
https://www.ncbi.nlm.nih.gov/pubmed/32982731
http://dx.doi.org/10.3389/fphar.2020.01300
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author Salehi, Bahare
Sharifi-Rad, Javad
Cappellini, Francesca
Reiner, Željko
Zorzan, Debora
Imran, Muhammad
Sener, Bilge
Kilic, Mehtap
El-Shazly, Mohamed
Fahmy, Nouran M.
Al-Sayed, Eman
Martorell, Miquel
Tonelli, Chiara
Petroni, Katia
Docea, Anca Oana
Calina, Daniela
Maroyi, Alfred
author_facet Salehi, Bahare
Sharifi-Rad, Javad
Cappellini, Francesca
Reiner, Željko
Zorzan, Debora
Imran, Muhammad
Sener, Bilge
Kilic, Mehtap
El-Shazly, Mohamed
Fahmy, Nouran M.
Al-Sayed, Eman
Martorell, Miquel
Tonelli, Chiara
Petroni, Katia
Docea, Anca Oana
Calina, Daniela
Maroyi, Alfred
author_sort Salehi, Bahare
collection PubMed
description Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.
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spelling pubmed-74791772020-09-26 The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action Salehi, Bahare Sharifi-Rad, Javad Cappellini, Francesca Reiner, Željko Zorzan, Debora Imran, Muhammad Sener, Bilge Kilic, Mehtap El-Shazly, Mohamed Fahmy, Nouran M. Al-Sayed, Eman Martorell, Miquel Tonelli, Chiara Petroni, Katia Docea, Anca Oana Calina, Daniela Maroyi, Alfred Front Pharmacol Pharmacology Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects. Frontiers Media S.A. 2020-08-26 /pmc/articles/PMC7479177/ /pubmed/32982731 http://dx.doi.org/10.3389/fphar.2020.01300 Text en Copyright © 2020 Salehi, Sharifi-Rad, Cappellini, Reiner, Zorzan, Imran, Sener, Kilic, El-Shazly, Fahmy, Al-Sayed, Martorell, Tonelli, Petroni, Docea, Calina and Maroyi http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Salehi, Bahare
Sharifi-Rad, Javad
Cappellini, Francesca
Reiner, Željko
Zorzan, Debora
Imran, Muhammad
Sener, Bilge
Kilic, Mehtap
El-Shazly, Mohamed
Fahmy, Nouran M.
Al-Sayed, Eman
Martorell, Miquel
Tonelli, Chiara
Petroni, Katia
Docea, Anca Oana
Calina, Daniela
Maroyi, Alfred
The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
title The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
title_full The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
title_fullStr The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
title_full_unstemmed The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
title_short The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
title_sort therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479177/
https://www.ncbi.nlm.nih.gov/pubmed/32982731
http://dx.doi.org/10.3389/fphar.2020.01300
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