First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations

The prognostics implications of patients with acute myeloid leukemia harboring non-canonical FLT3 is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driver FLT3 alterations in...

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Autores principales: Daver, Naval, Price, Allyson, Benton, Christopher B., Patel, Keyur, Zhang, Weiguo, Konopleva, Marina, Pemmaraju, Naveen, Takahashi, Koichi, Andreeff, Michael, Borthakur, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479234/
https://www.ncbi.nlm.nih.gov/pubmed/32984009
http://dx.doi.org/10.3389/fonc.2020.01538
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author Daver, Naval
Price, Allyson
Benton, Christopher B.
Patel, Keyur
Zhang, Weiguo
Konopleva, Marina
Pemmaraju, Naveen
Takahashi, Koichi
Andreeff, Michael
Borthakur, Gautam
author_facet Daver, Naval
Price, Allyson
Benton, Christopher B.
Patel, Keyur
Zhang, Weiguo
Konopleva, Marina
Pemmaraju, Naveen
Takahashi, Koichi
Andreeff, Michael
Borthakur, Gautam
author_sort Daver, Naval
collection PubMed
description The prognostics implications of patients with acute myeloid leukemia harboring non-canonical FLT3 is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driver FLT3 alterations in two patient case studies with acute myeloid leukemia.
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spelling pubmed-74792342020-09-26 First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations Daver, Naval Price, Allyson Benton, Christopher B. Patel, Keyur Zhang, Weiguo Konopleva, Marina Pemmaraju, Naveen Takahashi, Koichi Andreeff, Michael Borthakur, Gautam Front Oncol Oncology The prognostics implications of patients with acute myeloid leukemia harboring non-canonical FLT3 is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driver FLT3 alterations in two patient case studies with acute myeloid leukemia. Frontiers Media S.A. 2020-08-26 /pmc/articles/PMC7479234/ /pubmed/32984009 http://dx.doi.org/10.3389/fonc.2020.01538 Text en Copyright © 2020 Daver, Price, Benton, Patel, Zhang, Konopleva, Pemmaraju, Takahashi, Andreeff and Borthakur. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Daver, Naval
Price, Allyson
Benton, Christopher B.
Patel, Keyur
Zhang, Weiguo
Konopleva, Marina
Pemmaraju, Naveen
Takahashi, Koichi
Andreeff, Michael
Borthakur, Gautam
First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
title First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
title_full First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
title_fullStr First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
title_full_unstemmed First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
title_short First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
title_sort first report of sorafenib in patients with acute myeloid leukemia harboring non-canonical flt3 mutations
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479234/
https://www.ncbi.nlm.nih.gov/pubmed/32984009
http://dx.doi.org/10.3389/fonc.2020.01538
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