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Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation
OBJECTIVE: It is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS). METHODS: Fifteen adults with PCS...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479250/ https://www.ncbi.nlm.nih.gov/pubmed/32939420 http://dx.doi.org/10.1016/j.cnp.2020.07.004 |
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author | Locke, Mitchell B. Toepp, Stephen L. Turco, Claudia V. Harasym, Diana H. Rathbone, Michel P. Noseworthy, Michael D. Nelson, Aimee J. |
author_facet | Locke, Mitchell B. Toepp, Stephen L. Turco, Claudia V. Harasym, Diana H. Rathbone, Michel P. Noseworthy, Michael D. Nelson, Aimee J. |
author_sort | Locke, Mitchell B. |
collection | PubMed |
description | OBJECTIVE: It is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS). METHODS: Fifteen adults with PCS and 13 healthy, non-injured adults were tested. All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant motor cortex. RESULTS: Cortical silent period (p = 0.02, g = 0.96) and ipsilateral silent period (p = 0.04, g = 0.78) were shorter in the PCS group compared to the control group which may reflect reduced GABA-mediated inhibition in PCS. Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere. CONCLUSIONS: These data suggest that persistent neurophysiological differences are present in those with PCS. The exact contributing factors to such changes remain to be investigated by future studies. SIGNIFICANCE: This study provides novel evidence of lasting neurophysiological changes in PCS. |
format | Online Article Text |
id | pubmed-7479250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74792502020-09-15 Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation Locke, Mitchell B. Toepp, Stephen L. Turco, Claudia V. Harasym, Diana H. Rathbone, Michel P. Noseworthy, Michael D. Nelson, Aimee J. Clin Neurophysiol Pract Research Paper OBJECTIVE: It is unclear why specific individuals incur chronic symptoms following a concussion. This exploratory research aims to identify and characterize any neurophysiological differences that may exist in motor cortex function in post-concussion syndrome (PCS). METHODS: Fifteen adults with PCS and 13 healthy, non-injured adults were tested. All participants completed symptom questionnaires, and transcranial magnetic stimulation (TMS) was used to measure intracortical and transcallosal excitability and inhibition in the dominant motor cortex. RESULTS: Cortical silent period (p = 0.02, g = 0.96) and ipsilateral silent period (p = 0.04, g = 0.78) were shorter in the PCS group compared to the control group which may reflect reduced GABA-mediated inhibition in PCS. Furthermore, increased corticomotor excitability was observed in the left hemisphere but not the right hemisphere. CONCLUSIONS: These data suggest that persistent neurophysiological differences are present in those with PCS. The exact contributing factors to such changes remain to be investigated by future studies. SIGNIFICANCE: This study provides novel evidence of lasting neurophysiological changes in PCS. Elsevier 2020-08-06 /pmc/articles/PMC7479250/ /pubmed/32939420 http://dx.doi.org/10.1016/j.cnp.2020.07.004 Text en © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Locke, Mitchell B. Toepp, Stephen L. Turco, Claudia V. Harasym, Diana H. Rathbone, Michel P. Noseworthy, Michael D. Nelson, Aimee J. Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
title | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
title_full | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
title_fullStr | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
title_full_unstemmed | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
title_short | Altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
title_sort | altered motor system function in post-concussion syndrome as assessed via transcranial magnetic stimulation |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479250/ https://www.ncbi.nlm.nih.gov/pubmed/32939420 http://dx.doi.org/10.1016/j.cnp.2020.07.004 |
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