High-Resolution Histological Landscape of AAV DNA Distribution in Cellular Compartments and Tissues following Local and Systemic Injection

Adeno-associated virus (AAV) is one of the most important gene delivery vehicles for in vivo gene therapy. Intramuscular (i.m.) and intravascular (i.v.) injection are commonly used for AAV gene transfer. Unfortunately, the fate of AAV vectors following administration remains unclear at the histologi...

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Detalles Bibliográficos
Autores principales: Zhao, Junling, Yue, Yongping, Patel, Aman, Wasala, Lakmini, Karp, Jacob F., Zhang, Keqing, Duan, Dongsheng, Lai, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479330/
https://www.ncbi.nlm.nih.gov/pubmed/32953935
http://dx.doi.org/10.1016/j.omtm.2020.08.006

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