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Extramedullary Leukemia, Presenting at the Cervix of the Uterus

Extramedullary relapse of leukemia is encountered more often than in the past. The reason is that leukemia survival rates increase with improved treatment schemes. We present a rare case of involvement of the cervix of the uterus in an adult B Acute Lymphocytic Leukemia (B-ALL) survivor. Relapses af...

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Autores principales: Tsagkas, Nikolaos, Troussa, Androniki, Vorgias, George, Tzaida, Olympia, Zagorianakou, Nektaria, Gonidi, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479477/
https://www.ncbi.nlm.nih.gov/pubmed/32934855
http://dx.doi.org/10.1155/2020/8492036
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author Tsagkas, Nikolaos
Troussa, Androniki
Vorgias, George
Tzaida, Olympia
Zagorianakou, Nektaria
Gonidi, Maria
author_facet Tsagkas, Nikolaos
Troussa, Androniki
Vorgias, George
Tzaida, Olympia
Zagorianakou, Nektaria
Gonidi, Maria
author_sort Tsagkas, Nikolaos
collection PubMed
description Extramedullary relapse of leukemia is encountered more often than in the past. The reason is that leukemia survival rates increase with improved treatment schemes. We present a rare case of involvement of the cervix of the uterus in an adult B Acute Lymphocytic Leukemia (B-ALL) survivor. Relapses affect various organs but rarely the female genital tract. Nevertheless, in this case, a woman with a history of induced amenorrhea due to treatment for leukemia presented to the gynecologist because of vaginal spotting. Colposcopy evaluation of the vagina/cervix, sonography and cytological and histological sampling established the diagnosis of leukemia relapse in the cervix of the uterus. Under these circumstances, our study highlights the rare extramedullary presentation of leukemia in the cervix of the uterus of a young lady considered to be disease-free and listed for bone marrow transplantation. In this rare case of relapse in the cervix of the uterus, Pap smears alarmed physicians, and radiology examinations assisted the diagnostic workup. Still, only biopsy, microscopic evaluation, and immunohistochemistry studies established the exact diagnosis. Prognosis in the situation of extramedullary disease relapse in the female genital tract was poor, but gynecologists' high suspicion led to a prompt diagnosis. Survival is in general limited, but together with high suspicion, multidisciplinary team involvement is imperative to improve the reduced chances of survival.
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spelling pubmed-74794772020-09-14 Extramedullary Leukemia, Presenting at the Cervix of the Uterus Tsagkas, Nikolaos Troussa, Androniki Vorgias, George Tzaida, Olympia Zagorianakou, Nektaria Gonidi, Maria Case Rep Obstet Gynecol Case Report Extramedullary relapse of leukemia is encountered more often than in the past. The reason is that leukemia survival rates increase with improved treatment schemes. We present a rare case of involvement of the cervix of the uterus in an adult B Acute Lymphocytic Leukemia (B-ALL) survivor. Relapses affect various organs but rarely the female genital tract. Nevertheless, in this case, a woman with a history of induced amenorrhea due to treatment for leukemia presented to the gynecologist because of vaginal spotting. Colposcopy evaluation of the vagina/cervix, sonography and cytological and histological sampling established the diagnosis of leukemia relapse in the cervix of the uterus. Under these circumstances, our study highlights the rare extramedullary presentation of leukemia in the cervix of the uterus of a young lady considered to be disease-free and listed for bone marrow transplantation. In this rare case of relapse in the cervix of the uterus, Pap smears alarmed physicians, and radiology examinations assisted the diagnostic workup. Still, only biopsy, microscopic evaluation, and immunohistochemistry studies established the exact diagnosis. Prognosis in the situation of extramedullary disease relapse in the female genital tract was poor, but gynecologists' high suspicion led to a prompt diagnosis. Survival is in general limited, but together with high suspicion, multidisciplinary team involvement is imperative to improve the reduced chances of survival. Hindawi 2020-08-31 /pmc/articles/PMC7479477/ /pubmed/32934855 http://dx.doi.org/10.1155/2020/8492036 Text en Copyright © 2020 Nikolaos Tsagkas et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tsagkas, Nikolaos
Troussa, Androniki
Vorgias, George
Tzaida, Olympia
Zagorianakou, Nektaria
Gonidi, Maria
Extramedullary Leukemia, Presenting at the Cervix of the Uterus
title Extramedullary Leukemia, Presenting at the Cervix of the Uterus
title_full Extramedullary Leukemia, Presenting at the Cervix of the Uterus
title_fullStr Extramedullary Leukemia, Presenting at the Cervix of the Uterus
title_full_unstemmed Extramedullary Leukemia, Presenting at the Cervix of the Uterus
title_short Extramedullary Leukemia, Presenting at the Cervix of the Uterus
title_sort extramedullary leukemia, presenting at the cervix of the uterus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479477/
https://www.ncbi.nlm.nih.gov/pubmed/32934855
http://dx.doi.org/10.1155/2020/8492036
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