Cargando…
Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans
Experiences trigger transgenerational small RNA-based responses in C. elegans nematodes. Dedicated machinery ensures that heritable effects are reset, but how the responses segregate in the population is unknown. We show that isogenic individuals differ dramatically in the persistence of transgenera...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479518/ https://www.ncbi.nlm.nih.gov/pubmed/32841602 http://dx.doi.org/10.1016/j.cell.2020.07.022 |
_version_ | 1783580290478768128 |
---|---|
author | Houri-Zeevi, Leah Korem Kohanim, Yael Antonova, Olga Rechavi, Oded |
author_facet | Houri-Zeevi, Leah Korem Kohanim, Yael Antonova, Olga Rechavi, Oded |
author_sort | Houri-Zeevi, Leah |
collection | PubMed |
description | Experiences trigger transgenerational small RNA-based responses in C. elegans nematodes. Dedicated machinery ensures that heritable effects are reset, but how the responses segregate in the population is unknown. We show that isogenic individuals differ dramatically in the persistence of transgenerational responses. By examining lineages of more than 20,000 worms, three principles emerge: (1) The silencing each mother initiates is distributed evenly among her descendants; heritable RNAi dissipates but is uniform in every generation. (2) Differences between lineages arise because the mothers that initiate heritable responses stochastically assume different “inheritance states” that determine the progeny’s fate. (3) The likelihood that an RNAi response would continue to be inherited increases the more generations it lasts. The inheritance states are determined by HSF-1, which regulates silencing factors and, accordingly, small RNA levels. We found that, based on the parents’ inheritance state, the descendants’ developmental rate in response to stress can be predicted. |
format | Online Article Text |
id | pubmed-7479518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74795182020-09-16 Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans Houri-Zeevi, Leah Korem Kohanim, Yael Antonova, Olga Rechavi, Oded Cell Article Experiences trigger transgenerational small RNA-based responses in C. elegans nematodes. Dedicated machinery ensures that heritable effects are reset, but how the responses segregate in the population is unknown. We show that isogenic individuals differ dramatically in the persistence of transgenerational responses. By examining lineages of more than 20,000 worms, three principles emerge: (1) The silencing each mother initiates is distributed evenly among her descendants; heritable RNAi dissipates but is uniform in every generation. (2) Differences between lineages arise because the mothers that initiate heritable responses stochastically assume different “inheritance states” that determine the progeny’s fate. (3) The likelihood that an RNAi response would continue to be inherited increases the more generations it lasts. The inheritance states are determined by HSF-1, which regulates silencing factors and, accordingly, small RNA levels. We found that, based on the parents’ inheritance state, the descendants’ developmental rate in response to stress can be predicted. Cell Press 2020-09-03 /pmc/articles/PMC7479518/ /pubmed/32841602 http://dx.doi.org/10.1016/j.cell.2020.07.022 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Houri-Zeevi, Leah Korem Kohanim, Yael Antonova, Olga Rechavi, Oded Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans |
title | Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans |
title_full | Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans |
title_fullStr | Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans |
title_full_unstemmed | Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans |
title_short | Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans |
title_sort | three rules explain transgenerational small rna inheritance in c. elegans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479518/ https://www.ncbi.nlm.nih.gov/pubmed/32841602 http://dx.doi.org/10.1016/j.cell.2020.07.022 |
work_keys_str_mv | AT hourizeevileah threerulesexplaintransgenerationalsmallrnainheritanceincelegans AT koremkohanimyael threerulesexplaintransgenerationalsmallrnainheritanceincelegans AT antonovaolga threerulesexplaintransgenerationalsmallrnainheritanceincelegans AT rechavioded threerulesexplaintransgenerationalsmallrnainheritanceincelegans |