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Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations

During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmark...

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Autores principales: Kuruvilla, Maneesh V., Wilson, David I. G., Ainge, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479866/
https://www.ncbi.nlm.nih.gov/pubmed/32954005
http://dx.doi.org/10.1177/2398212820939463
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author Kuruvilla, Maneesh V.
Wilson, David I. G.
Ainge, James A.
author_facet Kuruvilla, Maneesh V.
Wilson, David I. G.
Ainge, James A.
author_sort Kuruvilla, Maneesh V.
collection PubMed
description During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmarks. In particular, the lateral (LEC) and medial (MEC) sub-regions of the entorhinal cortex have been shown to attend to proximal and distal landmarks, respectively. Recent studies have identified a further dissociation in cue processing between the LEC and MEC based on spatial frames of reference. Neurons in the LEC preferentially encode egocentric cues while those in the MEC encode allocentric cues. In this study, we assessed the impact of disrupting the LEC on landmark-based spatial memory in both egocentric and allocentric reference frames. Animals that received excitotoxic lesions of the LEC were significantly impaired, relative to controls, on both egocentric and allocentric versions of an object–place association task. Notably, LEC lesioned animals performed at chance on the egocentric version but above chance on the allocentric version. There was no significant difference in performance between the two groups on an object recognition and spatial T-maze task. Taken together, these results indicate that the LEC plays a role in feature integration more broadly and in specifically processing spatial information within an egocentric reference frame.
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spelling pubmed-74798662020-09-17 Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations Kuruvilla, Maneesh V. Wilson, David I. G. Ainge, James A. Brain Neurosci Adv Within and beyond the medial temporal lobe: brain circuits and mechanisms of recognition and place memory During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmarks. In particular, the lateral (LEC) and medial (MEC) sub-regions of the entorhinal cortex have been shown to attend to proximal and distal landmarks, respectively. Recent studies have identified a further dissociation in cue processing between the LEC and MEC based on spatial frames of reference. Neurons in the LEC preferentially encode egocentric cues while those in the MEC encode allocentric cues. In this study, we assessed the impact of disrupting the LEC on landmark-based spatial memory in both egocentric and allocentric reference frames. Animals that received excitotoxic lesions of the LEC were significantly impaired, relative to controls, on both egocentric and allocentric versions of an object–place association task. Notably, LEC lesioned animals performed at chance on the egocentric version but above chance on the allocentric version. There was no significant difference in performance between the two groups on an object recognition and spatial T-maze task. Taken together, these results indicate that the LEC plays a role in feature integration more broadly and in specifically processing spatial information within an egocentric reference frame. SAGE Publications 2020-07-14 /pmc/articles/PMC7479866/ /pubmed/32954005 http://dx.doi.org/10.1177/2398212820939463 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Within and beyond the medial temporal lobe: brain circuits and mechanisms of recognition and place memory
Kuruvilla, Maneesh V.
Wilson, David I. G.
Ainge, James A.
Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
title Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
title_full Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
title_fullStr Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
title_full_unstemmed Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
title_short Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
title_sort lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
topic Within and beyond the medial temporal lobe: brain circuits and mechanisms of recognition and place memory
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479866/
https://www.ncbi.nlm.nih.gov/pubmed/32954005
http://dx.doi.org/10.1177/2398212820939463
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