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The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk

Alzheimer's disease (AD) is an age-related neurodegenerative disease and the leading cause of dementia in the elderly. Recent decades have been marked by considerable advances in our understanding of genetic and environmental risk factors and also of the AD mechanism(s) of action. Nonetheless,...

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Autor principal: Kikis, Elise A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479932/
https://www.ncbi.nlm.nih.gov/pubmed/32810423
http://dx.doi.org/10.1098/rsob.200146
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author Kikis, Elise A.
author_facet Kikis, Elise A.
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description Alzheimer's disease (AD) is an age-related neurodegenerative disease and the leading cause of dementia in the elderly. Recent decades have been marked by considerable advances in our understanding of genetic and environmental risk factors and also of the AD mechanism(s) of action. Nonetheless, there is still no cure and the myriad ways AD affects the brain is overwhelmingly complex. Such complexity is manifest in part by the fact that genetic background interacts with the environment, including traffic-derived particulate air pollution, to greatly exacerbate AD risk. Determining the mechanisms by which particulate air pollution acts as an AD risk factor has the potential to reveal yet unknown aspects of AD pathology. This review carefully peels back the layers of complexity to discern whether a unifying disease model, one with proteostasis imbalance at its core, holds up to scrutiny in light of the recent literature. While the data are compelling, it is now time for carefully designed studies to definitively determine whether particulate air pollution acts with ageing, genetic background and other sources of proteotoxic stress to disrupt the delicate proteostasis balance.
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spelling pubmed-74799322020-09-09 The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk Kikis, Elise A. Open Biol Open Questions Alzheimer's disease (AD) is an age-related neurodegenerative disease and the leading cause of dementia in the elderly. Recent decades have been marked by considerable advances in our understanding of genetic and environmental risk factors and also of the AD mechanism(s) of action. Nonetheless, there is still no cure and the myriad ways AD affects the brain is overwhelmingly complex. Such complexity is manifest in part by the fact that genetic background interacts with the environment, including traffic-derived particulate air pollution, to greatly exacerbate AD risk. Determining the mechanisms by which particulate air pollution acts as an AD risk factor has the potential to reveal yet unknown aspects of AD pathology. This review carefully peels back the layers of complexity to discern whether a unifying disease model, one with proteostasis imbalance at its core, holds up to scrutiny in light of the recent literature. While the data are compelling, it is now time for carefully designed studies to definitively determine whether particulate air pollution acts with ageing, genetic background and other sources of proteotoxic stress to disrupt the delicate proteostasis balance. The Royal Society 2020-08-19 /pmc/articles/PMC7479932/ /pubmed/32810423 http://dx.doi.org/10.1098/rsob.200146 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Open Questions
Kikis, Elise A.
The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk
title The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk
title_full The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk
title_fullStr The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk
title_full_unstemmed The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk
title_short The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk
title_sort proteostatic effects of traffic-derived air pollution on alzheimer's disease risk
topic Open Questions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479932/
https://www.ncbi.nlm.nih.gov/pubmed/32810423
http://dx.doi.org/10.1098/rsob.200146
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