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Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China

The pandemic of novel coronavirus disease 2019 (COVID-19) began in Wuhan, China, where a first wave of intense community transmission was cut short by interventions. Using multiple data source, we estimated the disease burden and clinical severity of COVID-19 by age in Wuhan from December 1, 2019 to...

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Autores principales: Yang, Juan, Chen, Xinhua, Deng, Xiaowei, Chen, Zhiyuan, Gong, Hui, Yan, Han, Wu, Qianhui, Shi, Huilin, Lai, Shengjie, Ajelli, Marco, Viboud, Cecile, Yu, Hongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480068/
https://www.ncbi.nlm.nih.gov/pubmed/32909016
http://dx.doi.org/10.1101/2020.08.27.20183228
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author Yang, Juan
Chen, Xinhua
Deng, Xiaowei
Chen, Zhiyuan
Gong, Hui
Yan, Han
Wu, Qianhui
Shi, Huilin
Lai, Shengjie
Ajelli, Marco
Viboud, Cecile
Yu, Hongjie
author_facet Yang, Juan
Chen, Xinhua
Deng, Xiaowei
Chen, Zhiyuan
Gong, Hui
Yan, Han
Wu, Qianhui
Shi, Huilin
Lai, Shengjie
Ajelli, Marco
Viboud, Cecile
Yu, Hongjie
author_sort Yang, Juan
collection PubMed
description The pandemic of novel coronavirus disease 2019 (COVID-19) began in Wuhan, China, where a first wave of intense community transmission was cut short by interventions. Using multiple data source, we estimated the disease burden and clinical severity of COVID-19 by age in Wuhan from December 1, 2019 to March 31, 2020. We adjusted estimates for sensitivity of laboratory assays and accounted for prospective community screenings and healthcare seeking behaviors. Rates of symptomatic cases, medical consultations, hospitalizations and deaths were estimated at 796 (95%CI: 703–977), 489 (472–509), 370 (358–384), and 36.2 (35.0–37.3) per 100,000 persons, respectively. The COVID-19 outbreak in Wuhan had higher burden than the 2009 influenza pandemic or seasonal influenza, and that clinical severity was similar to that of the 1918 influenza pandemic. Our comparison puts the COVID-19 pandemic into context and could be helpful to guide intervention strategies and preparedness for the potential resurgence of COVID-19.
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spelling pubmed-74800682020-09-10 Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China Yang, Juan Chen, Xinhua Deng, Xiaowei Chen, Zhiyuan Gong, Hui Yan, Han Wu, Qianhui Shi, Huilin Lai, Shengjie Ajelli, Marco Viboud, Cecile Yu, Hongjie medRxiv Article The pandemic of novel coronavirus disease 2019 (COVID-19) began in Wuhan, China, where a first wave of intense community transmission was cut short by interventions. Using multiple data source, we estimated the disease burden and clinical severity of COVID-19 by age in Wuhan from December 1, 2019 to March 31, 2020. We adjusted estimates for sensitivity of laboratory assays and accounted for prospective community screenings and healthcare seeking behaviors. Rates of symptomatic cases, medical consultations, hospitalizations and deaths were estimated at 796 (95%CI: 703–977), 489 (472–509), 370 (358–384), and 36.2 (35.0–37.3) per 100,000 persons, respectively. The COVID-19 outbreak in Wuhan had higher burden than the 2009 influenza pandemic or seasonal influenza, and that clinical severity was similar to that of the 1918 influenza pandemic. Our comparison puts the COVID-19 pandemic into context and could be helpful to guide intervention strategies and preparedness for the potential resurgence of COVID-19. Cold Spring Harbor Laboratory 2020-09-01 /pmc/articles/PMC7480068/ /pubmed/32909016 http://dx.doi.org/10.1101/2020.08.27.20183228 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/It is made available under a CC-BY-NC-ND 4.0 International license (http://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Article
Yang, Juan
Chen, Xinhua
Deng, Xiaowei
Chen, Zhiyuan
Gong, Hui
Yan, Han
Wu, Qianhui
Shi, Huilin
Lai, Shengjie
Ajelli, Marco
Viboud, Cecile
Yu, Hongjie
Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
title Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
title_full Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
title_fullStr Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
title_full_unstemmed Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
title_short Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China
title_sort disease burden and clinical severity of the first pandemic wave of covid-19 in wuhan, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480068/
https://www.ncbi.nlm.nih.gov/pubmed/32909016
http://dx.doi.org/10.1101/2020.08.27.20183228
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