PTEN dephosphorylates Abi1 to promote epithelial morphogenesis

The tumor suppressor PTEN is essential for early development. Its lipid phosphatase activity converts PIP(3) to PIP(2) and antagonizes the PI3K–Akt pathway. In this study, we demonstrate that PTEN’s protein phosphatase activity is required for epiblast epithelial differentiation and polarization. Th...

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Detalles Bibliográficos
Autores principales: Qi, Yanmei, Liu, Jie, Chao, Joshua, Greer, Peter A., Li, Shaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480098/
https://www.ncbi.nlm.nih.gov/pubmed/32673396
http://dx.doi.org/10.1083/jcb.201910041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480098/
https://www.ncbi.nlm.nih.gov/pubmed/32673396
http://dx.doi.org/10.1083/jcb.201910041

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