Cargando…
PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
The tumor suppressor PTEN is essential for early development. Its lipid phosphatase activity converts PIP(3) to PIP(2) and antagonizes the PI3K–Akt pathway. In this study, we demonstrate that PTEN’s protein phosphatase activity is required for epiblast epithelial differentiation and polarization. Th...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480098/ https://www.ncbi.nlm.nih.gov/pubmed/32673396 http://dx.doi.org/10.1083/jcb.201910041 |