EGF receptor–mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling

Excessive accumulation of collagen leads to fibrosis. Integrin α1β1 (Itgα1β1) prevents kidney fibrosis by reducing collagen production through inhibition of the EGF receptor (EGFR) that phosphorylates cytoplasmic and nuclear proteins. To elucidate how the Itgα1β1/EGFR axis controls collagen synthesi...

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Detalles Bibliográficos
Autores principales: Chiusa, Manuel, Hu, Wen, Zienkiewicz, Jozef, Chen, Xiwu, Zhang, Ming-Zhi, Harris, Raymond C., Vanacore, Roberto M., Bentz, Jennifer A., Remuzzi, Giuseppe, Benigni, Ariela, Fogo, Agnes B., Luo, Wentian, Mili, Stavroula, Wilson, Matthew H., Zent, Roy, Hawiger, Jacek, Pozzi, Ambra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480104/
https://www.ncbi.nlm.nih.gov/pubmed/32678881
http://dx.doi.org/10.1083/jcb.202001120

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