Programming pluripotent stem cells: Can't teach an old cell new DNA replication tricks

Pluripotent stem cells differentiate with varying efficiencies depending on the method of reprogramming that created them. In this issue, Paniza et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201909163) demonstrate that cells with lower differentiation potential retain some features of soma...

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Detalles Bibliográficos
Autores principales: Mouery, Brandon L., Mei, Liu, Cook, Jeanette Gowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480109/
https://www.ncbi.nlm.nih.gov/pubmed/32858750
http://dx.doi.org/10.1083/jcb.202008014
Descripción
Sumario:Pluripotent stem cells differentiate with varying efficiencies depending on the method of reprogramming that created them. In this issue, Paniza et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201909163) demonstrate that cells with lower differentiation potential retain some features of somatic DNA replication origin utilization and suffer more frequent DNA damage.

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