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EZH2 regulates sFRP4 expression without affecting the methylation of sFRP4 promoter DNA in colorectal cancer cell lines

Abnormal activation of the Wnt signaling pathway is found in 90% of colorectal cancers (CRCs). Secreted frizzled-related protein 4 (sFRP4) serves as an antagonist of the canonical Wnt signaling pathway. Epigenetic alterations, including changes in DNA methylation and histone methylation, may influen...

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Detalles Bibliográficos
Autores principales:	Liu, Yuting, Yu, Jun, Xie, Yang, Li, Mengying, Wang, Feng, Zhang, Jing, Qi, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480130/ https://www.ncbi.nlm.nih.gov/pubmed/32952624 http://dx.doi.org/10.3892/etm.2020.9160

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