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Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles

Originally identified as lymphocyte regulation of fellow lymphocytes, our understanding of infectious tolerance has undergone significant evolutions in understanding since being proposed in the early 1970s by Gershon and Kondo and expanded upon by Herman Waldman two decades later. The evolution of o...

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Autores principales: Sullivan, Jeremy A., AlAdra, David P., Olson, Brian M., McNeel, Douglas G., Burlingham, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480133/
https://www.ncbi.nlm.nih.gov/pubmed/32983104
http://dx.doi.org/10.3389/fimmu.2020.01867
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author Sullivan, Jeremy A.
AlAdra, David P.
Olson, Brian M.
McNeel, Douglas G.
Burlingham, William J.
author_facet Sullivan, Jeremy A.
AlAdra, David P.
Olson, Brian M.
McNeel, Douglas G.
Burlingham, William J.
author_sort Sullivan, Jeremy A.
collection PubMed
description Originally identified as lymphocyte regulation of fellow lymphocytes, our understanding of infectious tolerance has undergone significant evolutions in understanding since being proposed in the early 1970s by Gershon and Kondo and expanded upon by Herman Waldman two decades later. The evolution of our understanding of infectious tolerance has coincided with significant cellular and humoral discoveries. The early studies leading to the isolation and identification of Regulatory T cells (Tregs) and cytokines including TGFβ and IL-10 in the control of peripheral tolerance was a paradigm shift in our understanding of infectious tolerance. More recently, another potential, paradigm shift in our understanding of the “infectious” aspect of infectious tolerance was proposed, identifying extracellular vesicles (EVs) as a mechanism for propagating infectious tolerance. In this review, we will outline the history of infectious tolerance, focusing on a potential EV mechanism for infectious tolerance and a novel, EV-associated form for the cytokine IL-35, ideally suited to the task of propagating tolerance by “infecting” other lymphocytes.
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spelling pubmed-74801332020-09-24 Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles Sullivan, Jeremy A. AlAdra, David P. Olson, Brian M. McNeel, Douglas G. Burlingham, William J. Front Immunol Immunology Originally identified as lymphocyte regulation of fellow lymphocytes, our understanding of infectious tolerance has undergone significant evolutions in understanding since being proposed in the early 1970s by Gershon and Kondo and expanded upon by Herman Waldman two decades later. The evolution of our understanding of infectious tolerance has coincided with significant cellular and humoral discoveries. The early studies leading to the isolation and identification of Regulatory T cells (Tregs) and cytokines including TGFβ and IL-10 in the control of peripheral tolerance was a paradigm shift in our understanding of infectious tolerance. More recently, another potential, paradigm shift in our understanding of the “infectious” aspect of infectious tolerance was proposed, identifying extracellular vesicles (EVs) as a mechanism for propagating infectious tolerance. In this review, we will outline the history of infectious tolerance, focusing on a potential EV mechanism for infectious tolerance and a novel, EV-associated form for the cytokine IL-35, ideally suited to the task of propagating tolerance by “infecting” other lymphocytes. Frontiers Media S.A. 2020-08-26 /pmc/articles/PMC7480133/ /pubmed/32983104 http://dx.doi.org/10.3389/fimmu.2020.01867 Text en Copyright © 2020 Sullivan, AlAdra, Olson, McNeel and Burlingham. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sullivan, Jeremy A.
AlAdra, David P.
Olson, Brian M.
McNeel, Douglas G.
Burlingham, William J.
Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles
title Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles
title_full Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles
title_fullStr Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles
title_full_unstemmed Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles
title_short Infectious Tolerance as Seen With 2020 Vision: The Role of IL-35 and Extracellular Vesicles
title_sort infectious tolerance as seen with 2020 vision: the role of il-35 and extracellular vesicles
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480133/
https://www.ncbi.nlm.nih.gov/pubmed/32983104
http://dx.doi.org/10.3389/fimmu.2020.01867
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