Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?()

The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of r...

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Autores principales: Asai, Nobuhiro, Sakanashi, Daisuke, Ohashi, Wataru, Nakamura, Akiko, Yamada, Atsuko, Kawamoto, Yuzuka, Miyazaki, Narimi, Ohno, Tomoko, Koita, Isao, Suematsu, Hiroyuki, Kishino, Takaaki, Kato, Hideo, Hagihara, Mao, Shiota, Arufumi, Koizumi, Yusuke, Yamagishi, Yuka, Mikamo, Hiroshige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480734/
https://www.ncbi.nlm.nih.gov/pubmed/32994136
http://dx.doi.org/10.1016/j.jiac.2020.09.010
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author Asai, Nobuhiro
Sakanashi, Daisuke
Ohashi, Wataru
Nakamura, Akiko
Yamada, Atsuko
Kawamoto, Yuzuka
Miyazaki, Narimi
Ohno, Tomoko
Koita, Isao
Suematsu, Hiroyuki
Kishino, Takaaki
Kato, Hideo
Hagihara, Mao
Shiota, Arufumi
Koizumi, Yusuke
Yamagishi, Yuka
Mikamo, Hiroshige
author_facet Asai, Nobuhiro
Sakanashi, Daisuke
Ohashi, Wataru
Nakamura, Akiko
Yamada, Atsuko
Kawamoto, Yuzuka
Miyazaki, Narimi
Ohno, Tomoko
Koita, Isao
Suematsu, Hiroyuki
Kishino, Takaaki
Kato, Hideo
Hagihara, Mao
Shiota, Arufumi
Koizumi, Yusuke
Yamagishi, Yuka
Mikamo, Hiroshige
author_sort Asai, Nobuhiro
collection PubMed
description The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than 2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered.
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spelling pubmed-74807342020-09-09 Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?() Asai, Nobuhiro Sakanashi, Daisuke Ohashi, Wataru Nakamura, Akiko Yamada, Atsuko Kawamoto, Yuzuka Miyazaki, Narimi Ohno, Tomoko Koita, Isao Suematsu, Hiroyuki Kishino, Takaaki Kato, Hideo Hagihara, Mao Shiota, Arufumi Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige J Infect Chemother Note The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than 2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021-01 2020-09-09 /pmc/articles/PMC7480734/ /pubmed/32994136 http://dx.doi.org/10.1016/j.jiac.2020.09.010 Text en © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Note
Asai, Nobuhiro
Sakanashi, Daisuke
Ohashi, Wataru
Nakamura, Akiko
Yamada, Atsuko
Kawamoto, Yuzuka
Miyazaki, Narimi
Ohno, Tomoko
Koita, Isao
Suematsu, Hiroyuki
Kishino, Takaaki
Kato, Hideo
Hagihara, Mao
Shiota, Arufumi
Koizumi, Yusuke
Yamagishi, Yuka
Mikamo, Hiroshige
Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?()
title Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?()
title_full Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?()
title_fullStr Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?()
title_full_unstemmed Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?()
title_short Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?()
title_sort could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (covid-19)?()
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480734/
https://www.ncbi.nlm.nih.gov/pubmed/32994136
http://dx.doi.org/10.1016/j.jiac.2020.09.010
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