Cancer proteome and metabolite changes linked to SHMT2

Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers. In order to better understand the role of SHMT2 in cancer a model system of HeLa cells engineered for inducible ove...

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Detalles Bibliográficos
Autores principales: Tong, Jiefei, Krieger, Jonathan R., Taylor, Paul, Bagshaw, Rick, Kang, Jae, Jeedigunta, Swathi, Wybenga-Groot, Leanne E., Zhang, Wen, Badr, Heba, Mirhadi, Shideh, Pham, Nhu-An, Coyaud, Étienne, Yu, Man, Li, Ming, Cabanero, Michael, Raught, Brian, Maynes, Jason T., Hawkins, Cynthia, Tsao, Ming Sound, Moran, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480864/
https://www.ncbi.nlm.nih.gov/pubmed/32903271
http://dx.doi.org/10.1371/journal.pone.0237981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480864/
https://www.ncbi.nlm.nih.gov/pubmed/32903271
http://dx.doi.org/10.1371/journal.pone.0237981

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