Cargando…

Cancer proteome and metabolite changes linked to SHMT2

Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers. In order to better understand the role of SHMT2 in cancer a model system of HeLa cells engineered for inducible ove...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tong, Jiefei, Krieger, Jonathan R., Taylor, Paul, Bagshaw, Rick, Kang, Jae, Jeedigunta, Swathi, Wybenga-Groot, Leanne E., Zhang, Wen, Badr, Heba, Mirhadi, Shideh, Pham, Nhu-An, Coyaud, Étienne, Yu, Man, Li, Ming, Cabanero, Michael, Raught, Brian, Maynes, Jason T., Hawkins, Cynthia, Tsao, Ming Sound, Moran, Michael F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480864/ https://www.ncbi.nlm.nih.gov/pubmed/32903271 http://dx.doi.org/10.1371/journal.pone.0237981

Ejemplares similares

Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
por: Mirhadi, Shideh, et al.
Publicado: (2023)

Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes
por: Mirhadi, Shideh, et al.
Publicado: (2022)

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis
por: Anderson, Donald D., et al.
Publicado: (2009)

The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-terminal amphipathic α-helix
por: Odeh, Hana M., et al.
Publicado: (2018)

Tumor-Associated Regulatory T Cell Expression of LAIR2 Is Prognostic in Lung Adenocarcinoma
por: Ly, Dalam, et al.
Publicado: (2021)

SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma
por: Ning, Shanglei, et al.
Publicado: (2018)

SHMT2 Induces Stemness and Progression of Head and Neck Cancer
por: Jin, Yanli, et al.
Publicado: (2022)

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
por: García-Cañaveras, Juan C., et al.
Publicado: (2020)

Metabolic control of BRISC-SHMT2 assembly regulates immune signaling
por: Walden, Miriam, et al.
Publicado: (2019)

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis
por: Zeng, Yuanyuan, et al.
Publicado: (2021)

SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer
por: Jin, Meihua, et al.
Publicado: (2021)

Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2
por: Jin, Xiuxiu, et al.
Publicado: (2022)

Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis
por: Pham, Nhu-An, et al.
Publicado: (2008)

Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma
por: Radulovich, Nikolina, et al.
Publicado: (2010)

SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer
por: Komlósi, Viktor, et al.
Publicado: (2010)

Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2
por: Tramonti, Angela, et al.
Publicado: (2021)

SHMT2 Drives the Progression of Colorectal Cancer by Regulating UHRF1 Expression
por: Cui, Ximao, et al.
Publicado: (2022)

FLOURY ENDOSPERM20 encoding SHMT4 is required for rice endosperm development
por: Yan, Mengyuan, et al.
Publicado: (2022)

Understanding The Regulatory Role of USP32 and SHMT2 in The Progression of Gastric Cancer
por: Li, Jun, et al.
Publicado: (2023)

Optimizing Drug Response Study Design in Patient-Derived Tumor Xenografts
por: Weiss, Jessica, et al.
Publicado: (2022)

Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer
por: Wang, Dennis, et al.
Publicado: (2019)

PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN
por: Sydor, Andrew Michael, et al.
Publicado: (2018)

SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling
por: Wang, Weida, et al.
Publicado: (2023)

Characterizing the last holdouts
por: Stewart, Erin L., et al.
Publicado: (2017)

SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis
por: Kim, Bo Ram, et al.
Publicado: (2016)

A systematic proximity map of the centriole-cilia interface
por: Gonçalves, J, et al.
Publicado: (2015)

Spatiotemporal distribution of small ubiquitin‐like modifiers during human placental development and in response to oxidative and inflammatory stress
por: Baczyk, Dora, et al.
Publicado: (2018)

USP7 Regulates Cytokinesis through FBXO38 and KIF20B
por: Georges, Anna, et al.
Publicado: (2019)

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation
por: Paone, A, et al.
Publicado: (2014)

Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma
por: Woo, Chern Chiuh, et al.
Publicado: (2016)

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal
por: Tani, Haruna, et al.
Publicado: (2018)

SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production
por: Dou, Changwei, et al.
Publicado: (2019)

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy
por: Chen, Jian, et al.
Publicado: (2021)

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline
por: Lieber, Toby, et al.
Publicado: (2019)

SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance
por: Kim, Dohoon, et al.
Publicado: (2015)

Modified gateway system for double shRNA expression and Cre/lox based gene expression
por: Radulovich, Nikolina, et al.
Publicado: (2011)

The in vivo Interaction Landscape of Histones H3.1 and H3.3
por: Siddaway, Robert, et al.
Publicado: (2022)

Biochemical and Computational Analysis Of LNX1 Interacting Proteins
por: Wolting, Cheryl D., et al.
Publicado: (2011)

Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors
por: Bernhardt, Stephan, et al.
Publicado: (2017)

HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
por: Cao, Ji, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uk3u7tkvo4dau4u2en647vni0o