Cargando…
Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis
Standard treatment for active tuberculosis (TB) requires drug treatment with at least four drugs over six months. Shorter-duration therapy would mean less need for strict adherence, and reduced risk of bacterial resistance. A system pharmacology model of TB infection, and drug therapy was developed...
Autores principales: | Fors, John, Strydom, Natasha, Fox, William S., Keizer, Ron J., Savic, Radojka M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480878/ https://www.ncbi.nlm.nih.gov/pubmed/32810158 http://dx.doi.org/10.1371/journal.pcbi.1008107 |
Ejemplares similares
-
Tuberculosis drugs’ distribution and emergence of resistance in patient’s lung lesions: A mechanistic model and tool for regimen and dose optimization
por: Strydom, Natasha, et al.
Publicado: (2019) -
Model-Based Efficacy and Toxicity Comparisons of Moxifloxacin for Multidrug-Resistant Tuberculosis
por: Yun, Hwi-Yeol, et al.
Publicado: (2021) -
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis
por: Ernest, Jacqueline P., et al.
Publicado: (2021) -
Drug concentration at the site of disease in children with pulmonary tuberculosis
por: Lopez-Varela, Elisa, et al.
Publicado: (2022) -
Precision-Enhancing Risk Stratification Tools for Selecting Optimal Treatment Durations in Tuberculosis Clinical Trials
por: Imperial, Marjorie Z., et al.
Publicado: (2021)