Cargando…

(11)C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis

OBJECTIVE: Neuroinflammation is considered a key driver for neurodegeneration in several neurological diseases, including amyotrophic lateral sclerosis (ALS). SOD1 mutations cause about 20% of familial ALS, and related pathology might generate microglial activation triggering neurodegeneration. (11)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tondo, Giacomo, Iaccarino, Leonardo, Cerami, Chiara, Vanoli, Giovanna Emilia, Presotto, Luca, Masiello, Valeria, Coliva, Angela, Salvi, Fabrizio, Bartolomei, Ilaria, Mosca, Lorena, Lunetta, Christian, Perani, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480909/ https://www.ncbi.nlm.nih.gov/pubmed/32762033 http://dx.doi.org/10.1002/acn3.51112

Ejemplares similares

An in vivo (11)C‐PK PET study of microglia activation in Fatal Familial Insomnia
por: Iaccarino, Leonardo, et al.
Publicado: (2017)

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease
por: Tondo, Giacomo, et al.
Publicado: (2020)

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
por: Guedes, Carlos Eduardo Sampaio, et al.
Publicado: (2018)

[(11)C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy
por: Passamonti, Luca, et al.
Publicado: (2018)

Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.
por: da Silva, Marcelo Barreto Spillere, et al.
Publicado: (2004)

Abnormal neuroinflammation in fibromyalgia and CRPS using [(11)C]-(R)-PK11195 PET
por: Seo, Seongho, et al.
Publicado: (2021)

The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
por: Ye, Chen, et al.
Publicado: (2020)

(11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
por: Nicastro, Nicolas, et al.
Publicado: (2019)

[(11)C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease
por: van den Ameele, Jelle, et al.
Publicado: (2021)

Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [(11)C]-(R)-PK11195 PET and MRI
por: Yankam Njiwa, J, et al.
Publicado: (2016)

Textural properties of microglial activation in Alzheimer’s disease as measured by (R)-[(11)C]PK11195 PET
por: Lapo Pais, Marta, et al.
Publicado: (2023)

Carotid artery plaque uptake of (11)C-PK11195 inversely correlates with circulating monocytes and classical CD14(++)CD16(−) monocytes expressing HLA-DR
por: Ammirati, Enrico, et al.
Publicado: (2018)

The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy
por: Lan, Nannan, et al.
Publicado: (2021)

Molecular Imaging of Neuroinflammation in Neurodegenerative Dementias: The Role of In Vivo PET Imaging
por: Cerami, Chiara, et al.
Publicado: (2017)

[(18)F]DPA-714: Direct Comparison with [(11)C]PK11195 in a Model of Cerebral Ischemia in Rats
por: Boutin, Hervé, et al.
Publicado: (2013)

[(11)C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches
por: Su, Zhangjie, et al.
Publicado: (2013)

Noninvasive PK11195‐PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease
por: Kang, Yeona, et al.
Publicado: (2018)

PK11195 Protects From Cell Death Only When Applied During Reperfusion: Succinate-Mediated Mechanism of Action
por: Seidlmayer, Lea K., et al.
Publicado: (2021)

FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort
por: Caminiti, Silvia Paola, et al.
Publicado: (2018)

Low-dose CT for the spatial normalization of PET images: A validation procedure for amyloid-PET semi-quantification
por: Presotto, Luca, et al.
Publicado: (2018)

Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
por: Kumar, Ajay, et al.
Publicado: (2012)

In vivo (R)-[(11)C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis
por: van der Doef, Thalia F, et al.
Publicado: (2016)

[(11)C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study
por: Jeon, So Yeon, et al.
Publicado: (2017)

Test-retest reliability and convergent validity of (R)-[(11)C]PK11195 outcome measures without arterial input function
por: Plavén-Sigray, Pontus, et al.
Publicado: (2018)

TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells
por: Feng, Hao, et al.
Publicado: (2020)

Have (R)-[(11)C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies
por: Chauveau, Fabien, et al.
Publicado: (2021)

Potential of [(11)C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model
por: de Souza, Aline Morais, et al.
Publicado: (2022)

Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species
por: Fennell, D A, et al.
Publicado: (2001)

Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies
por: Yaqub, Maqsood, et al.
Publicado: (2012)

No Signs of Neuroinflammation in Women With Chronic Fatigue Syndrome or Q Fever Fatigue Syndrome Using the TSPO Ligand [(11)C]-PK11195
por: Raijmakers, Ruud, et al.
Publicado: (2021)

The Effect of the Classical TSPO Ligand PK 11195 on In Vitro Cobalt Chloride Model of Hypoxia-like Condition in Lung and Brain Cell Lines
por: Amara, Rula, et al.
Publicado: (2022)

Evaluation of (R)-[(11)C]PK11195 PET/MRI for Spinal Cord-Related Neuropathic Pain in Patients with Cervical Spinal Disorders
por: Kitade, Makoto, et al.
Publicado: (2022)

PT637. [11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: a pilot study
por: Jeon, Soyeon
Publicado: (2016)

Analysis of PK11195 concentrations in rodent whole blood and tissue samples by rapid and reproducible chromatographic method to support target-occupancy PET studies
por: Stadulytė, Agnė, et al.
Publicado: (2019)

(11)C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-sectional study
por: de Souza, Aline Morais, et al.
Publicado: (2021)

In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer’s Brain Tissue
por: Ni, Ruiqing, et al.
Publicado: (2021)

The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS
por: Azrad, Maya, et al.
Publicado: (2019)

The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore
por: Baburina, Yulia, et al.
Publicado: (2020)

SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis
por: Tafuri, Francesco, et al.
Publicado: (2015)

Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
por: Folkersma, Hedy, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_odi0mlfblc5vr395d4uupurr7o