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Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies

OBJECTIVE: (18)F‐FP‐CIT and (123)I‐FP‐CIT are widely used radiotracers in molecular imaging for Parkinson’s disease (PD) diagnosis. Compared with (123)I‐FP‐CIT, (18)F‐FP‐CIT has superior tracer kinetics. We aimed to conduct a meta‐analysis to assess the efficacy of using (18)F‐FP‐CIT positron emissi...

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Autores principales: Kong, Yanyan, Zhang, Chencheng, Liu, Kawai, Wagle Shukla, Aparna, Sun, Bomin, Guan, Yihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480930/
https://www.ncbi.nlm.nih.gov/pubmed/32794655
http://dx.doi.org/10.1002/acn3.51122
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author Kong, Yanyan
Zhang, Chencheng
Liu, Kawai
Wagle Shukla, Aparna
Sun, Bomin
Guan, Yihui
author_facet Kong, Yanyan
Zhang, Chencheng
Liu, Kawai
Wagle Shukla, Aparna
Sun, Bomin
Guan, Yihui
author_sort Kong, Yanyan
collection PubMed
description OBJECTIVE: (18)F‐FP‐CIT and (123)I‐FP‐CIT are widely used radiotracers in molecular imaging for Parkinson’s disease (PD) diagnosis. Compared with (123)I‐FP‐CIT, (18)F‐FP‐CIT has superior tracer kinetics. We aimed to conduct a meta‐analysis to assess the efficacy of using (18)F‐FP‐CIT positron emission tomography (PET) and (123)I‐FP‐CIT single‐photon emission computed tomography (SPECT) of dopamine transporters in patients with PD in order to provide evidence for clinical decision‐making. METHODS: We searched the PubMed, Embase, Wanfang Data, and China National Knowledge Infrastructure databases to identify the relevant studies from the time of inception of the databases to 30 April 2020. We identified six PET studies, including 779 patients with PD and 124 healthy controls, which met the inclusion criteria. Twenty‐seven SPECT studies with 1244 PD patients and 859 controls were also included in this meta‐analysis. RESULTS: Overall effect‐size analysis indicated that patients with PD showed significantly reduced (18)F‐FP‐CIT uptake in three brain regions [caudate nucleus: standardized mean difference (SMD) = −1.71, Z = −3.31, P = 0.0009; anterior putamen: SMD = −3.71, Z = −6.26, P < 0.0001; and posterior putamen: SMD = −5.49, Z = −5.97, P < 0.0001]. Significant decreases of (123)I‐FP‐CIT uptake were also observed in the caudate (SMD = −2.31, Z = −11.49, P < 0.0001) and putamen (SMD = −3.25, Z = −14.79, P < 0.0001). INTERPRETATION: In conclusion, our findings indicate that both (18)F‐FP‐CIT PET and (123)I‐FP‐CIT SPECT imaging of dopamine transporters can provide viable biomarkers for early PD diagnosis.
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spelling pubmed-74809302020-09-16 Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies Kong, Yanyan Zhang, Chencheng Liu, Kawai Wagle Shukla, Aparna Sun, Bomin Guan, Yihui Ann Clin Transl Neurol Research Articles OBJECTIVE: (18)F‐FP‐CIT and (123)I‐FP‐CIT are widely used radiotracers in molecular imaging for Parkinson’s disease (PD) diagnosis. Compared with (123)I‐FP‐CIT, (18)F‐FP‐CIT has superior tracer kinetics. We aimed to conduct a meta‐analysis to assess the efficacy of using (18)F‐FP‐CIT positron emission tomography (PET) and (123)I‐FP‐CIT single‐photon emission computed tomography (SPECT) of dopamine transporters in patients with PD in order to provide evidence for clinical decision‐making. METHODS: We searched the PubMed, Embase, Wanfang Data, and China National Knowledge Infrastructure databases to identify the relevant studies from the time of inception of the databases to 30 April 2020. We identified six PET studies, including 779 patients with PD and 124 healthy controls, which met the inclusion criteria. Twenty‐seven SPECT studies with 1244 PD patients and 859 controls were also included in this meta‐analysis. RESULTS: Overall effect‐size analysis indicated that patients with PD showed significantly reduced (18)F‐FP‐CIT uptake in three brain regions [caudate nucleus: standardized mean difference (SMD) = −1.71, Z = −3.31, P = 0.0009; anterior putamen: SMD = −3.71, Z = −6.26, P < 0.0001; and posterior putamen: SMD = −5.49, Z = −5.97, P < 0.0001]. Significant decreases of (123)I‐FP‐CIT uptake were also observed in the caudate (SMD = −2.31, Z = −11.49, P < 0.0001) and putamen (SMD = −3.25, Z = −14.79, P < 0.0001). INTERPRETATION: In conclusion, our findings indicate that both (18)F‐FP‐CIT PET and (123)I‐FP‐CIT SPECT imaging of dopamine transporters can provide viable biomarkers for early PD diagnosis. John Wiley and Sons Inc. 2020-08-14 /pmc/articles/PMC7480930/ /pubmed/32794655 http://dx.doi.org/10.1002/acn3.51122 Text en © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Kong, Yanyan
Zhang, Chencheng
Liu, Kawai
Wagle Shukla, Aparna
Sun, Bomin
Guan, Yihui
Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies
title Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies
title_full Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies
title_fullStr Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies
title_full_unstemmed Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies
title_short Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of (18)F/(123)I‐FP‐CIT studies
title_sort imaging of dopamine transporters in parkinson disease: a meta‐analysis of (18)f/(123)i‐fp‐cit studies
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480930/
https://www.ncbi.nlm.nih.gov/pubmed/32794655
http://dx.doi.org/10.1002/acn3.51122
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