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Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk
Preterm birth accounts for over 15 million global births per year. Perinatal interventions introduced since the early 1980s, such as antenatal glucocorticoids, surfactant, and invasive ventilation strategies, have dramatically improved survival of even the smallest, most vulnerable neonates. As a re...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480939/ https://www.ncbi.nlm.nih.gov/pubmed/32816574 http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15574 |
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author | Lewandowski, Adam J. Levy, Philip T. Bates, Melissa L. McNamara, Patrick J. Nuyt, Anne Monique Goss, Kara N. |
author_facet | Lewandowski, Adam J. Levy, Philip T. Bates, Melissa L. McNamara, Patrick J. Nuyt, Anne Monique Goss, Kara N. |
author_sort | Lewandowski, Adam J. |
collection | PubMed |
description | Preterm birth accounts for over 15 million global births per year. Perinatal interventions introduced since the early 1980s, such as antenatal glucocorticoids, surfactant, and invasive ventilation strategies, have dramatically improved survival of even the smallest, most vulnerable neonates. As a result, a new generation of preterm-born individuals has now reached early adulthood, and they are at increased risk of cardiovascular diseases. To better understand the sequelae of preterm birth, cardiovascular follow-up studies in adolescents and young adults born preterm have focused on characterizing changes in cardiac, vascular, and pulmonary structure and function. Being born preterm associates with a reduced cardiac reserve and smaller left and right ventricular volumes, as well as decreased vascularity, increased vascular stiffness, and higher pressure of both the pulmonary and systemic vasculature. The purpose of this review is to present major epidemiological evidence linking preterm birth with cardiovascular disease; to discuss findings from clinical studies showing a long-term impact of preterm birth on cardiac remodeling, as well as the systemic and pulmonary vascular systems; to discuss differences across gestational ages; and to consider possible driving mechanisms and therapeutic approaches for reducing cardiovascular burden in individuals born preterm. |
format | Online Article Text |
id | pubmed-7480939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-74809392020-09-24 Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk Lewandowski, Adam J. Levy, Philip T. Bates, Melissa L. McNamara, Patrick J. Nuyt, Anne Monique Goss, Kara N. Hypertension Reviews Preterm birth accounts for over 15 million global births per year. Perinatal interventions introduced since the early 1980s, such as antenatal glucocorticoids, surfactant, and invasive ventilation strategies, have dramatically improved survival of even the smallest, most vulnerable neonates. As a result, a new generation of preterm-born individuals has now reached early adulthood, and they are at increased risk of cardiovascular diseases. To better understand the sequelae of preterm birth, cardiovascular follow-up studies in adolescents and young adults born preterm have focused on characterizing changes in cardiac, vascular, and pulmonary structure and function. Being born preterm associates with a reduced cardiac reserve and smaller left and right ventricular volumes, as well as decreased vascularity, increased vascular stiffness, and higher pressure of both the pulmonary and systemic vasculature. The purpose of this review is to present major epidemiological evidence linking preterm birth with cardiovascular disease; to discuss findings from clinical studies showing a long-term impact of preterm birth on cardiac remodeling, as well as the systemic and pulmonary vascular systems; to discuss differences across gestational ages; and to consider possible driving mechanisms and therapeutic approaches for reducing cardiovascular burden in individuals born preterm. Lippincott Williams & Wilkins 2020-08-17 2020-10 /pmc/articles/PMC7480939/ /pubmed/32816574 http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15574 Text en © 2020 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited. |
spellingShingle | Reviews Lewandowski, Adam J. Levy, Philip T. Bates, Melissa L. McNamara, Patrick J. Nuyt, Anne Monique Goss, Kara N. Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk |
title | Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk |
title_full | Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk |
title_fullStr | Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk |
title_full_unstemmed | Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk |
title_short | Impact of the Vulnerable Preterm Heart and Circulation on Adult Cardiovascular Disease Risk |
title_sort | impact of the vulnerable preterm heart and circulation on adult cardiovascular disease risk |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480939/ https://www.ncbi.nlm.nih.gov/pubmed/32816574 http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15574 |
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