Cargando…
Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based reasoning, including in sensory preconditioning. This involvement could be accounted for by representation of value or by representation of broader associative structure. We recently reported neural correlates of...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481003/ https://www.ncbi.nlm.nih.gov/pubmed/32831173 http://dx.doi.org/10.7554/eLife.59998 |
_version_ | 1783580513978548224 |
---|---|
author | Hart, Evan E Sharpe, Melissa J Gardner, Matthew PH Schoenbaum, Geoffrey |
author_facet | Hart, Evan E Sharpe, Melissa J Gardner, Matthew PH Schoenbaum, Geoffrey |
author_sort | Hart, Evan E |
collection | PubMed |
description | The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based reasoning, including in sensory preconditioning. This involvement could be accounted for by representation of value or by representation of broader associative structure. We recently reported neural correlates of such broader associative structure in OFC during the initial phase of sensory preconditioning (Sadacca et al., 2018). Here, we used optogenetic inhibition of OFC to test whether these correlates might be necessary for value inference during later probe testing. We found that inhibition of OFC during cue-cue learning abolished value inference during the probe test, inference subsequently shown in control rats to be sensitive to devaluation of the expected reward. These results demonstrate that OFC must be online during cue-cue learning, consistent with the argument that the correlates previously observed are not simply downstream readouts of sensory processing and instead contribute to building the associative model supporting later behavior. |
format | Online Article Text |
id | pubmed-7481003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-74810032020-09-11 Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning Hart, Evan E Sharpe, Melissa J Gardner, Matthew PH Schoenbaum, Geoffrey eLife Neuroscience The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based reasoning, including in sensory preconditioning. This involvement could be accounted for by representation of value or by representation of broader associative structure. We recently reported neural correlates of such broader associative structure in OFC during the initial phase of sensory preconditioning (Sadacca et al., 2018). Here, we used optogenetic inhibition of OFC to test whether these correlates might be necessary for value inference during later probe testing. We found that inhibition of OFC during cue-cue learning abolished value inference during the probe test, inference subsequently shown in control rats to be sensitive to devaluation of the expected reward. These results demonstrate that OFC must be online during cue-cue learning, consistent with the argument that the correlates previously observed are not simply downstream readouts of sensory processing and instead contribute to building the associative model supporting later behavior. eLife Sciences Publications, Ltd 2020-08-24 /pmc/articles/PMC7481003/ /pubmed/32831173 http://dx.doi.org/10.7554/eLife.59998 Text en http://creativecommons.org/publicdomain/zero/1.0/ http://creativecommons.org/publicdomain/zero/1.0/This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) . |
spellingShingle | Neuroscience Hart, Evan E Sharpe, Melissa J Gardner, Matthew PH Schoenbaum, Geoffrey Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning |
title | Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning |
title_full | Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning |
title_fullStr | Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning |
title_full_unstemmed | Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning |
title_short | Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning |
title_sort | responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481003/ https://www.ncbi.nlm.nih.gov/pubmed/32831173 http://dx.doi.org/10.7554/eLife.59998 |
work_keys_str_mv | AT hartevane respondingtopreconditionedcuesisdevaluationsensitiveandrequiresorbitofrontalcortexduringcuecuelearning AT sharpemelissaj respondingtopreconditionedcuesisdevaluationsensitiveandrequiresorbitofrontalcortexduringcuecuelearning AT gardnermatthewph respondingtopreconditionedcuesisdevaluationsensitiveandrequiresorbitofrontalcortexduringcuecuelearning AT schoenbaumgeoffrey respondingtopreconditionedcuesisdevaluationsensitiveandrequiresorbitofrontalcortexduringcuecuelearning |