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Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning

The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based reasoning, including in sensory preconditioning. This involvement could be accounted for by representation of value or by representation of broader associative structure. We recently reported neural correlates of...

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Autores principales: Hart, Evan E, Sharpe, Melissa J, Gardner, Matthew PH, Schoenbaum, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481003/
https://www.ncbi.nlm.nih.gov/pubmed/32831173
http://dx.doi.org/10.7554/eLife.59998
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author Hart, Evan E
Sharpe, Melissa J
Gardner, Matthew PH
Schoenbaum, Geoffrey
author_facet Hart, Evan E
Sharpe, Melissa J
Gardner, Matthew PH
Schoenbaum, Geoffrey
author_sort Hart, Evan E
collection PubMed
description The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based reasoning, including in sensory preconditioning. This involvement could be accounted for by representation of value or by representation of broader associative structure. We recently reported neural correlates of such broader associative structure in OFC during the initial phase of sensory preconditioning (Sadacca et al., 2018). Here, we used optogenetic inhibition of OFC to test whether these correlates might be necessary for value inference during later probe testing. We found that inhibition of OFC during cue-cue learning abolished value inference during the probe test, inference subsequently shown in control rats to be sensitive to devaluation of the expected reward. These results demonstrate that OFC must be online during cue-cue learning, consistent with the argument that the correlates previously observed are not simply downstream readouts of sensory processing and instead contribute to building the associative model supporting later behavior.
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spelling pubmed-74810032020-09-11 Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning Hart, Evan E Sharpe, Melissa J Gardner, Matthew PH Schoenbaum, Geoffrey eLife Neuroscience The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based reasoning, including in sensory preconditioning. This involvement could be accounted for by representation of value or by representation of broader associative structure. We recently reported neural correlates of such broader associative structure in OFC during the initial phase of sensory preconditioning (Sadacca et al., 2018). Here, we used optogenetic inhibition of OFC to test whether these correlates might be necessary for value inference during later probe testing. We found that inhibition of OFC during cue-cue learning abolished value inference during the probe test, inference subsequently shown in control rats to be sensitive to devaluation of the expected reward. These results demonstrate that OFC must be online during cue-cue learning, consistent with the argument that the correlates previously observed are not simply downstream readouts of sensory processing and instead contribute to building the associative model supporting later behavior. eLife Sciences Publications, Ltd 2020-08-24 /pmc/articles/PMC7481003/ /pubmed/32831173 http://dx.doi.org/10.7554/eLife.59998 Text en http://creativecommons.org/publicdomain/zero/1.0/ http://creativecommons.org/publicdomain/zero/1.0/This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) .
spellingShingle Neuroscience
Hart, Evan E
Sharpe, Melissa J
Gardner, Matthew PH
Schoenbaum, Geoffrey
Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
title Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
title_full Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
title_fullStr Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
title_full_unstemmed Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
title_short Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
title_sort responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481003/
https://www.ncbi.nlm.nih.gov/pubmed/32831173
http://dx.doi.org/10.7554/eLife.59998
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