Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome

Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models, recovery of behavioral and neurophysiological deficits using GABA(A)R antagonists led to hypothesize an excessive activity of inhibitory circuits in this condition. Nonetheless, whether over-inhibition is presen...

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Detalles Bibliográficos
Autores principales: Zorrilla de San Martin, Javier, Donato, Cristina, Peixoto, Jérémy, Aguirre, Andrea, Choudhary, Vikash, De Stasi, Angela Michela, Lourenço, Joana, Potier, Marie-Claude, Bacci, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481006/
https://www.ncbi.nlm.nih.gov/pubmed/32783810
http://dx.doi.org/10.7554/eLife.58731

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