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Potential of electric stimulation for the management of COVID-19
The COVID-19 pandemic is the most devastating health emergency that humans have seen over the past century. The war against the disease has been handicapped by unavailability of effective therapeutic options. Till date, there is no clinically approved vaccine or drug for the treatment of COVID-19, a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481069/ https://www.ncbi.nlm.nih.gov/pubmed/33254561 http://dx.doi.org/10.1016/j.mehy.2020.110259 |
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author | Allawadhi, Prince Khurana, Amit Allwadhi, Sachin Navik, Uma Shanker Joshi, Kamaldeep Banothu, Anil Kumar Bharani, Kala Kumar |
author_facet | Allawadhi, Prince Khurana, Amit Allwadhi, Sachin Navik, Uma Shanker Joshi, Kamaldeep Banothu, Anil Kumar Bharani, Kala Kumar |
author_sort | Allawadhi, Prince |
collection | PubMed |
description | The COVID-19 pandemic is the most devastating health emergency that humans have seen over the past century. The war against the disease has been handicapped by unavailability of effective therapeutic options. Till date, there is no clinically approved vaccine or drug for the treatment of COVID-19, and the ongoing search to find a novel therapy is progressing at pandemic pace. Herein, we propose a novel hypothesis based on sound research evidence that electric stimulation can be a potential adjuvant to the currently used symptomatic therapies and antiviral drugs. Based on preclinical evidence, we propose that electric stimulation can improve respiratory functions, inhibit SARS-CoV-2 growth, reduce pain, boost immunity and improve the penetration of antiviral drugs. We envisage that our hypothesis, if used clinically as an adjuvant, may significantly improve the therapeutic outcomes of the current treatment regimen being used around the globe for the management of COVID-19. |
format | Online Article Text |
id | pubmed-7481069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74810692020-09-10 Potential of electric stimulation for the management of COVID-19 Allawadhi, Prince Khurana, Amit Allwadhi, Sachin Navik, Uma Shanker Joshi, Kamaldeep Banothu, Anil Kumar Bharani, Kala Kumar Med Hypotheses Article The COVID-19 pandemic is the most devastating health emergency that humans have seen over the past century. The war against the disease has been handicapped by unavailability of effective therapeutic options. Till date, there is no clinically approved vaccine or drug for the treatment of COVID-19, and the ongoing search to find a novel therapy is progressing at pandemic pace. Herein, we propose a novel hypothesis based on sound research evidence that electric stimulation can be a potential adjuvant to the currently used symptomatic therapies and antiviral drugs. Based on preclinical evidence, we propose that electric stimulation can improve respiratory functions, inhibit SARS-CoV-2 growth, reduce pain, boost immunity and improve the penetration of antiviral drugs. We envisage that our hypothesis, if used clinically as an adjuvant, may significantly improve the therapeutic outcomes of the current treatment regimen being used around the globe for the management of COVID-19. Elsevier Ltd. 2020-11 2020-09-10 /pmc/articles/PMC7481069/ /pubmed/33254561 http://dx.doi.org/10.1016/j.mehy.2020.110259 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Allawadhi, Prince Khurana, Amit Allwadhi, Sachin Navik, Uma Shanker Joshi, Kamaldeep Banothu, Anil Kumar Bharani, Kala Kumar Potential of electric stimulation for the management of COVID-19 |
title | Potential of electric stimulation for the management of COVID-19 |
title_full | Potential of electric stimulation for the management of COVID-19 |
title_fullStr | Potential of electric stimulation for the management of COVID-19 |
title_full_unstemmed | Potential of electric stimulation for the management of COVID-19 |
title_short | Potential of electric stimulation for the management of COVID-19 |
title_sort | potential of electric stimulation for the management of covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481069/ https://www.ncbi.nlm.nih.gov/pubmed/33254561 http://dx.doi.org/10.1016/j.mehy.2020.110259 |
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