Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs

Patients with the pre-leukemia bone marrow failure syndrome called severe congenital neutropenia (CN) have an approximately 15% risk of developing acute myeloid leukemia (AML; called here CN/AML). Most CN/AML patients co-acquire CSF3R and RUNX1 mutations, which play cooperative roles in the developm...

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Detalles Bibliográficos
Autores principales: Ritter, Malte, Klimiankou, Maksim, Klimenkova, Olga, Schambach, Axel, Hoffmann, Dirk, Schmidt, Amy, Kanz, Lothar, Link, Daniel C., Welte, Karl, Skokowa, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481169/
https://www.ncbi.nlm.nih.gov/pubmed/32821971
http://dx.doi.org/10.1007/s00277-020-04194-0

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