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Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs
Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481189/ https://www.ncbi.nlm.nih.gov/pubmed/32908208 http://dx.doi.org/10.1038/s41598-020-71691-7 |
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author | Angrimani, Daniel S. R. Brito, Maíra M. Rui, Bruno R. Nichi, Marcílio Vannucchi, Camila I. |
author_facet | Angrimani, Daniel S. R. Brito, Maíra M. Rui, Bruno R. Nichi, Marcílio Vannucchi, Camila I. |
author_sort | Angrimani, Daniel S. R. |
collection | PubMed |
description | Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects are scarce. Thus, the aim of this study was to evaluate the effects of BPH and short-term (2 months) finasteride therapy on clinical, endocrinological, and reproductive parameters in dogs. Dogs were allocated into four experimental groups: Non-affected (n = 5), BPH (n = 5), Non-Affected-Finasteride (n = 5) and BPH-Finasteride (n = 5) groups. Dogs were evaluated monthly during 2 months by a complete breeding soundness examination, B-mode ultrasound and Doppler ultrasonography of the testicular artery, hormonal profile (testosterone, estrogen and dihydrotestosterone) and oxidative profile of the prostatic fluid. After 2 months, dogs were gonadectomized and testicles were subjected to histologic analysis. Finasteride treatment reduced dihydrotestosterone concentrations, without negative influence on semen quality and also reverted testicular hemodynamics changes of BPH. On the other hand, BPH was accompanied by significant changes in testosterone and estrogen concentrations and semen quality, mainly related to sperm kinetics alterations. In conclusion, BPH dogs have important hormonal and sperm alterations, however, short-term finasteride treatment (2 months) was able to reduce overall effects of BPH, thus representing a method of therapy for BPH treatment. |
format | Online Article Text |
id | pubmed-7481189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74811892020-09-11 Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs Angrimani, Daniel S. R. Brito, Maíra M. Rui, Bruno R. Nichi, Marcílio Vannucchi, Camila I. Sci Rep Article Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects are scarce. Thus, the aim of this study was to evaluate the effects of BPH and short-term (2 months) finasteride therapy on clinical, endocrinological, and reproductive parameters in dogs. Dogs were allocated into four experimental groups: Non-affected (n = 5), BPH (n = 5), Non-Affected-Finasteride (n = 5) and BPH-Finasteride (n = 5) groups. Dogs were evaluated monthly during 2 months by a complete breeding soundness examination, B-mode ultrasound and Doppler ultrasonography of the testicular artery, hormonal profile (testosterone, estrogen and dihydrotestosterone) and oxidative profile of the prostatic fluid. After 2 months, dogs were gonadectomized and testicles were subjected to histologic analysis. Finasteride treatment reduced dihydrotestosterone concentrations, without negative influence on semen quality and also reverted testicular hemodynamics changes of BPH. On the other hand, BPH was accompanied by significant changes in testosterone and estrogen concentrations and semen quality, mainly related to sperm kinetics alterations. In conclusion, BPH dogs have important hormonal and sperm alterations, however, short-term finasteride treatment (2 months) was able to reduce overall effects of BPH, thus representing a method of therapy for BPH treatment. Nature Publishing Group UK 2020-09-09 /pmc/articles/PMC7481189/ /pubmed/32908208 http://dx.doi.org/10.1038/s41598-020-71691-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Angrimani, Daniel S. R. Brito, Maíra M. Rui, Bruno R. Nichi, Marcílio Vannucchi, Camila I. Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs |
title | Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs |
title_full | Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs |
title_fullStr | Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs |
title_full_unstemmed | Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs |
title_short | Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs |
title_sort | reproductive and endocrinological effects of benign prostatic hyperplasia and finasteride therapy in dogs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481189/ https://www.ncbi.nlm.nih.gov/pubmed/32908208 http://dx.doi.org/10.1038/s41598-020-71691-7 |
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