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CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves
The velocity of nerve conduction is moderately enhanced by larger axonal diameters and potently sped up by myelination of axons. Myelination thus allows rapid impulse propagation with reduced axonal diameters; however, no myelin-dependent mechanism has been reported that restricts radial growth of a...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481192/ https://www.ncbi.nlm.nih.gov/pubmed/32908139 http://dx.doi.org/10.1038/s41467-020-18172-7 |
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author | Eichel, Maria A. Gargareta, Vasiliki-Ilya D’Este, Elisa Fledrich, Robert Kungl, Theresa Buscham, Tobias J. Lüders, Katja A. Miracle, Cristina Jung, Ramona B. Distler, Ute Kusch, Kathrin Möbius, Wiebke Hülsmann, Swen Tenzer, Stefan Nave, Klaus-Armin Werner, Hauke B. |
author_facet | Eichel, Maria A. Gargareta, Vasiliki-Ilya D’Este, Elisa Fledrich, Robert Kungl, Theresa Buscham, Tobias J. Lüders, Katja A. Miracle, Cristina Jung, Ramona B. Distler, Ute Kusch, Kathrin Möbius, Wiebke Hülsmann, Swen Tenzer, Stefan Nave, Klaus-Armin Werner, Hauke B. |
author_sort | Eichel, Maria A. |
collection | PubMed |
description | The velocity of nerve conduction is moderately enhanced by larger axonal diameters and potently sped up by myelination of axons. Myelination thus allows rapid impulse propagation with reduced axonal diameters; however, no myelin-dependent mechanism has been reported that restricts radial growth of axons. By label-free proteomics, STED-microscopy and cryo-immuno electron-microscopy we here identify CMTM6 (chemokine-like factor-like MARVEL-transmembrane domain-containing family member-6) as a myelin protein specifically localized to the Schwann cell membrane exposed to the axon. We find that disruption of Cmtm6-expression in Schwann cells causes a substantial increase of axonal diameters but does not impair myelin biogenesis, radial sorting or integrity of axons. Increased axonal diameters correlate with accelerated sensory nerve conduction and sensory responses and perturbed motor performance. These data show that Schwann cells utilize CMTM6 to restrict the radial growth of axons, which optimizes nerve function. |
format | Online Article Text |
id | pubmed-7481192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74811922020-09-21 CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves Eichel, Maria A. Gargareta, Vasiliki-Ilya D’Este, Elisa Fledrich, Robert Kungl, Theresa Buscham, Tobias J. Lüders, Katja A. Miracle, Cristina Jung, Ramona B. Distler, Ute Kusch, Kathrin Möbius, Wiebke Hülsmann, Swen Tenzer, Stefan Nave, Klaus-Armin Werner, Hauke B. Nat Commun Article The velocity of nerve conduction is moderately enhanced by larger axonal diameters and potently sped up by myelination of axons. Myelination thus allows rapid impulse propagation with reduced axonal diameters; however, no myelin-dependent mechanism has been reported that restricts radial growth of axons. By label-free proteomics, STED-microscopy and cryo-immuno electron-microscopy we here identify CMTM6 (chemokine-like factor-like MARVEL-transmembrane domain-containing family member-6) as a myelin protein specifically localized to the Schwann cell membrane exposed to the axon. We find that disruption of Cmtm6-expression in Schwann cells causes a substantial increase of axonal diameters but does not impair myelin biogenesis, radial sorting or integrity of axons. Increased axonal diameters correlate with accelerated sensory nerve conduction and sensory responses and perturbed motor performance. These data show that Schwann cells utilize CMTM6 to restrict the radial growth of axons, which optimizes nerve function. Nature Publishing Group UK 2020-09-09 /pmc/articles/PMC7481192/ /pubmed/32908139 http://dx.doi.org/10.1038/s41467-020-18172-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Eichel, Maria A. Gargareta, Vasiliki-Ilya D’Este, Elisa Fledrich, Robert Kungl, Theresa Buscham, Tobias J. Lüders, Katja A. Miracle, Cristina Jung, Ramona B. Distler, Ute Kusch, Kathrin Möbius, Wiebke Hülsmann, Swen Tenzer, Stefan Nave, Klaus-Armin Werner, Hauke B. CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves |
title | CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves |
title_full | CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves |
title_fullStr | CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves |
title_full_unstemmed | CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves |
title_short | CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves |
title_sort | cmtm6 expressed on the adaxonal schwann cell surface restricts axonal diameters in peripheral nerves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481192/ https://www.ncbi.nlm.nih.gov/pubmed/32908139 http://dx.doi.org/10.1038/s41467-020-18172-7 |
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