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Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review
Gait deficits are a common feature of Parkinson’s disease (PD) and predictors of future motor and cognitive impairment. Understanding how muscle activity contributes to gait impairment and effects of therapeutic interventions on motor behaviour is crucial for identifying potential biomarkers and dev...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481232/ https://www.ncbi.nlm.nih.gov/pubmed/32964107 http://dx.doi.org/10.1038/s41531-020-00119-w |
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author | Islam, Aisha Alcock, Lisa Nazarpour, Kianoush Rochester, Lynn Pantall, Annette |
author_facet | Islam, Aisha Alcock, Lisa Nazarpour, Kianoush Rochester, Lynn Pantall, Annette |
author_sort | Islam, Aisha |
collection | PubMed |
description | Gait deficits are a common feature of Parkinson’s disease (PD) and predictors of future motor and cognitive impairment. Understanding how muscle activity contributes to gait impairment and effects of therapeutic interventions on motor behaviour is crucial for identifying potential biomarkers and developing rehabilitation strategies. This article reviews sixteen studies that investigate the electromyographic (EMG) activity of lower limb muscles in people with PD during walking and reports on their quality. The weight of evidence establishing differences in motor activity between people with PD and healthy older adults (HOAs) is considered. Additionally, the effect of dopaminergic medication and deep brain stimulation (DBS) on modifying motor activity is assessed. Results indicated greater proximal and decreased distal activity of lower limb muscles during walking in individuals with PD compared to HOA. Dopaminergic medication was associated with increased distal lower limb muscle activity whereas subthalamic nucleus DBS increased activity of both proximal and distal lower limb muscles. Tibialis anterior was impacted most by the interventions. Quality of the studies was not strong, with a median score of 61%. Most studies investigated only distal muscles, involved small sample sizes, extracted limited EMG features and lacked rigorous signal processing. Few studies related changes in motor activity with functional gait measures. Understanding mechanisms underpinning gait impairment in PD is essential for development of personalised rehabilitative interventions. Recommendations for future studies include greater participant numbers, recording more functionally diverse muscles, applying multi-muscle analyses, and relating EMG to functional gait measures. |
format | Online Article Text |
id | pubmed-7481232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74812322020-09-21 Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review Islam, Aisha Alcock, Lisa Nazarpour, Kianoush Rochester, Lynn Pantall, Annette NPJ Parkinsons Dis Review Article Gait deficits are a common feature of Parkinson’s disease (PD) and predictors of future motor and cognitive impairment. Understanding how muscle activity contributes to gait impairment and effects of therapeutic interventions on motor behaviour is crucial for identifying potential biomarkers and developing rehabilitation strategies. This article reviews sixteen studies that investigate the electromyographic (EMG) activity of lower limb muscles in people with PD during walking and reports on their quality. The weight of evidence establishing differences in motor activity between people with PD and healthy older adults (HOAs) is considered. Additionally, the effect of dopaminergic medication and deep brain stimulation (DBS) on modifying motor activity is assessed. Results indicated greater proximal and decreased distal activity of lower limb muscles during walking in individuals with PD compared to HOA. Dopaminergic medication was associated with increased distal lower limb muscle activity whereas subthalamic nucleus DBS increased activity of both proximal and distal lower limb muscles. Tibialis anterior was impacted most by the interventions. Quality of the studies was not strong, with a median score of 61%. Most studies investigated only distal muscles, involved small sample sizes, extracted limited EMG features and lacked rigorous signal processing. Few studies related changes in motor activity with functional gait measures. Understanding mechanisms underpinning gait impairment in PD is essential for development of personalised rehabilitative interventions. Recommendations for future studies include greater participant numbers, recording more functionally diverse muscles, applying multi-muscle analyses, and relating EMG to functional gait measures. Nature Publishing Group UK 2020-09-09 /pmc/articles/PMC7481232/ /pubmed/32964107 http://dx.doi.org/10.1038/s41531-020-00119-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Islam, Aisha Alcock, Lisa Nazarpour, Kianoush Rochester, Lynn Pantall, Annette Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review |
title | Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review |
title_full | Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review |
title_fullStr | Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review |
title_full_unstemmed | Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review |
title_short | Effect of Parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review |
title_sort | effect of parkinson’s disease and two therapeutic interventions on muscle activity during walking: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481232/ https://www.ncbi.nlm.nih.gov/pubmed/32964107 http://dx.doi.org/10.1038/s41531-020-00119-w |
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