Discovery of a selective, state-independent inhibitor of Na(V)1.7 by modification of guanidinium toxins

The voltage-gated sodium channel isoform Na(V)1.7 is highly expressed in dorsal root ganglion neurons and is obligatory for nociceptive signal transmission. Genetic gain-of-function and loss-of-function Na(V)1.7 mutations have been identified in select individuals, and are associated with episodic e...

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Detalles Bibliográficos
Autores principales: Pajouhesh, H., Beckley, J. T., Delwig, A., Hajare, H. S., Luu, G., Monteleone, D., Zhou, X., Ligutti, J., Amagasu, S., Moyer, B. D., Yeomans, D. C., Du Bois, J., Mulcahy, J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481244/
https://www.ncbi.nlm.nih.gov/pubmed/32908170
http://dx.doi.org/10.1038/s41598-020-71135-2

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