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HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation

ER-associated degradation (ERAD) targets misfolded ER proteins for degradation. Retrotranslocation, a key feature of ERAD, entails removal of ubiquitinated substrates into the cytosol for proteasomal destruction. Recently, it has been shown that the Hrd1 E3 ligase forms a retrotranslocation channel...

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Detalles Bibliográficos
Autores principales:	Neal, Sonya, Syau, Della, Nejatfard, Anahita, Nadeau, Samantha, Hampton, Randolph Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481253/ https://www.ncbi.nlm.nih.gov/pubmed/32891886 http://dx.doi.org/10.1016/j.isci.2020.101493

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