An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability

Small interfering RNAs (siRNAs) are potential tools for gene-silencing therapy, but their instability is one of the obstacles in the development of siRNA-based drugs. To improve siRNA stability, we synthesised a double-stranded RNA-binding cationic oligodiaminogalactose 4mer (ODAGal4) and investigat...

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Detalles Bibliográficos
Autores principales: Irie, Atsushi, Sato, Kazuki, Hara, Rintaro Iwata, Wada, Takeshi, Shibasaki, Futoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481297/
https://www.ncbi.nlm.nih.gov/pubmed/32908235
http://dx.doi.org/10.1038/s41598-020-71896-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481297/
https://www.ncbi.nlm.nih.gov/pubmed/32908235
http://dx.doi.org/10.1038/s41598-020-71896-w

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