Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer

Tumor-initiating cells (TICs) maintain heterogeneity within tumors and seed metastases at distant sites, contributing to therapeutic resistance and disease recurrence. In colorectal cancer (CRC), strategy that effectively eradicates TICs and is of potential value for clinical use still remains in ne...

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Detalles Bibliográficos
Autores principales: Zhang, Junbao, Ying, Ying, Li, Meiqi, Wang, Maolin, Huang, Xiaoyan, Jia, Min, Zeng, Junhui, Ma, Canjie, Zhang, Yixiang, Li, Chen, Wang, Xiaomei, Shu, Xing-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481431/
https://www.ncbi.nlm.nih.gov/pubmed/32929331
http://dx.doi.org/10.7150/thno.47081

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