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Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress

BACKGROUND AND AIM: Anxiety disorders are one of the most common psychiatric disorders worldwide. Common anti-anxiety medications are associated with several side effects. Caffeic acid (CA) is a phenolic compound with several pharmacological effects. The aim of this study was to investigate the anxi...

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Autores principales: Lorigooini, Zahra, Nasiri boroujeni, Shakiba, Balali-Dehkordi, Shima, Ebrahimi, Leila, Bijad, Elham, Rahimi-Madiseh, Mohammad, Amini-Khoei, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481568/
https://www.ncbi.nlm.nih.gov/pubmed/32944669
http://dx.doi.org/10.1016/j.heliyon.2020.e04833
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author Lorigooini, Zahra
Nasiri boroujeni, Shakiba
Balali-Dehkordi, Shima
Ebrahimi, Leila
Bijad, Elham
Rahimi-Madiseh, Mohammad
Amini-Khoei, Hossein
author_facet Lorigooini, Zahra
Nasiri boroujeni, Shakiba
Balali-Dehkordi, Shima
Ebrahimi, Leila
Bijad, Elham
Rahimi-Madiseh, Mohammad
Amini-Khoei, Hossein
author_sort Lorigooini, Zahra
collection PubMed
description BACKGROUND AND AIM: Anxiety disorders are one of the most common psychiatric disorders worldwide. Common anti-anxiety medications are associated with several side effects. Caffeic acid (CA) is a phenolic compound with several pharmacological effects. The aim of this study was to investigate the anxiolytic-like effect of CA in maternally separated (MS) mice focusing on the possible involvement of the NMDA receptor. MATERIALS AND METHODS: In this study, we used the MS paradigm (as a valid animal model of anxiety) in male mice and examined their anxiety-like behavior in postnatal day (PND) 45. The animals were divided into 12 experimental groups. Mice treated with CA alone and in combination with the NMDA receptor agonist/antagonist and then using open field (OFT) and elevated plus maze (EPM) anxiety-like behavior was assessed. Finally, the expression of NMDA receptor subtypes was assessed in the hippocampus using RT- PCR. RESULTS: Finding showed that CA exerted anxiolytic –like effects in the OFT and EPM tests. We showed that administration of effective dose of NMDA significantly reversed the anxiolytic-like effect of effective dose of CA and co-administration of ketamine (a NMDA receptor antagonist) significantly potentiated the effect of sub-effective dose of CA. Furthermore, ketamine enhanced the CA-reducing effect on NMDA receptors in the MS mice. CONCLUSION: Our finding demonstrated that, probably at least, NMDA receptors are involved in the anxiety-like properties of CA in MS mice.
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spelling pubmed-74815682020-09-16 Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress Lorigooini, Zahra Nasiri boroujeni, Shakiba Balali-Dehkordi, Shima Ebrahimi, Leila Bijad, Elham Rahimi-Madiseh, Mohammad Amini-Khoei, Hossein Heliyon Research Article BACKGROUND AND AIM: Anxiety disorders are one of the most common psychiatric disorders worldwide. Common anti-anxiety medications are associated with several side effects. Caffeic acid (CA) is a phenolic compound with several pharmacological effects. The aim of this study was to investigate the anxiolytic-like effect of CA in maternally separated (MS) mice focusing on the possible involvement of the NMDA receptor. MATERIALS AND METHODS: In this study, we used the MS paradigm (as a valid animal model of anxiety) in male mice and examined their anxiety-like behavior in postnatal day (PND) 45. The animals were divided into 12 experimental groups. Mice treated with CA alone and in combination with the NMDA receptor agonist/antagonist and then using open field (OFT) and elevated plus maze (EPM) anxiety-like behavior was assessed. Finally, the expression of NMDA receptor subtypes was assessed in the hippocampus using RT- PCR. RESULTS: Finding showed that CA exerted anxiolytic –like effects in the OFT and EPM tests. We showed that administration of effective dose of NMDA significantly reversed the anxiolytic-like effect of effective dose of CA and co-administration of ketamine (a NMDA receptor antagonist) significantly potentiated the effect of sub-effective dose of CA. Furthermore, ketamine enhanced the CA-reducing effect on NMDA receptors in the MS mice. CONCLUSION: Our finding demonstrated that, probably at least, NMDA receptors are involved in the anxiety-like properties of CA in MS mice. Elsevier 2020-09-03 /pmc/articles/PMC7481568/ /pubmed/32944669 http://dx.doi.org/10.1016/j.heliyon.2020.e04833 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Lorigooini, Zahra
Nasiri boroujeni, Shakiba
Balali-Dehkordi, Shima
Ebrahimi, Leila
Bijad, Elham
Rahimi-Madiseh, Mohammad
Amini-Khoei, Hossein
Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress
title Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress
title_full Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress
title_fullStr Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress
title_full_unstemmed Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress
title_short Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress
title_sort possible involvement of nmda receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481568/
https://www.ncbi.nlm.nih.gov/pubmed/32944669
http://dx.doi.org/10.1016/j.heliyon.2020.e04833
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