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PI3K-AKT-mTOR pathway alterations in advanced NSCLC patients after progression on EGFR-TKI and clinical response to EGFR-TKI plus everolimus combination therapy

BACKGROUND: Several mechanisms including abnormal activation of PI3K-AKT-mTOR pathway have been proved to generate acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). In this study, we investigated the genomic charac...

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Detalles Bibliográficos
Autores principales:	Fang, Wenfeng, Huang, Yihua, Gu, Weiguang, Gan, Jiadi, Wang, Wenjing, Zhang, Shiyue, Wang, Kai, Zhan, Jianhua, Yang, Yunpeng, Huang, Yan, Zhao, Hongyun, Zhang, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481581/ https://www.ncbi.nlm.nih.gov/pubmed/32953503 http://dx.doi.org/10.21037/tlcr-20-141

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